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Mechanical behavior and length adaptation of rabbit bladder smooth muscle.

机译：兔膀胱平滑肌的力学行为和长度适应。

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摘要

Overactive bladder (OAB), involuntary contractions during bladder filling, is a common condition affecting 17% of the adult population worldwide, and in the U.S. ranks ahead of diabetes in a list of the 10 most common chronic disorders (Mullins 2009). Mechanical mechanisms contributing to OAB are not completely understood and because of the unique function and broad volume range of the bladder, there may be mechanical characteristics that distinguish detrusor smooth muscle (DSM) in bladder from other smooth muscles.;Recent studies have shown that the length-passive tension curve in DSM exhibits adjustable passive stiffness (APS) characterized by a passive curve that can be shifted along the length axis as a function of strain history and activation history; however, the mechanical mechanisms responsible for APS remain to be determined. Also, whether DSM exhibits a dynamic length-active tension relationship, as has been identified in airway and vascular smooth muscles, has not been investigated.;This dissertation focused on both the passive and active length-tension relationships in DSM and the mechanical mechanisms responsible for these relationships. The first objective was to study the impact of APS on the length-total tension relationship and identify the mechanical mechanisms responsible for generating APS. The second objective was to determine whether the length-active tension relationship is adaptive and identify specific mechanical mechanisms contributing to any adaptive behavior.;The results showed that a shift in the length-passive tension curve due to APS corresponded with a shift in the length-total tension curve in DSM, and that APS was 27.0±8.4% of active tension at the optimum length for active tension generation. Most importantly, low-grade rhythmic contraction (RC), which can occur spontaneously in rabbit and human bladders, regenerated APS.;Results also showed that the length-active tension curve shifted due to stretch to and then activation at long lengths, as well as either multiple KCl-induced maximal contractions or RC. Thus, DSM exhibits length adaptation, and RC may contribute to both APS and length adaptation. Because increased RC has been correlated with OAB, understanding RC, APS and length-adaptation in bladder may enable the identification of specific targets for new treatments for OAB.
机译：膀胱过度活动症（OAB）是膀胱填充过程中的不自主收缩，是一种常见的疾病，影响了全世界17％的成年人口，在美国，它在10种最常见的慢性疾病中排名领先于糖尿病（Mullins 2009）。尚不完全了解导致OAB的机械机制，并且由于膀胱的独特功能和广泛的容积范围，可能存在将膀胱中逼尿肌平滑肌（DSM）与其他平滑肌区分开的机械特性。最近的研究表明， DSM中的长度-被动张力曲线表现出可调节的被动刚度（APS），其特征在于被动曲线可以沿着长度轴移动，这是应变历史和激活历史的函数；但是，负责APS的机械机制仍有待确定。并且，如在气道和血管平滑肌中所确定的那样，DSM是否表现出动态的长度-主动张力关系也没有得到研究。对于这些关系。第一个目标是研究APS对长度-总张力关系的影响，并确定产生APS的机械机制。第二个目标是确定长度-主动张力关系是否是自适应的，并确定导致任何自适应行为的特定机械机制;结果表明，APS引起的长度-被动张力曲线的变化与长度的变化相对应-DSM中的总张力曲线，并且在产生主动张力的最佳长度下，APS为主动张力的27.0±8.4％。最重要的是，低度节律性收缩（RC）可以在兔和人的膀胱中自发发生，可以再生APS .;结果还表明，长度-主动张力曲线由于拉伸到而移动，然后在较长的长度上激活作为多个KCl诱导的最大收缩或RC。因此，DSM表现出长度适应性，而RC可能有助于APS和长度适应性。由于RC增加与OAB相关，因此了解RC，APS和膀胱长度适应可能有助于确定OAB新疗法的具体靶标。

著录项

  • 作者

    Almasri, Atheer Mohammad.;

  • 作者单位

    Virginia Commonwealth University.;

  • 授予单位 Virginia Commonwealth University.;
  • 学科 Engineering Mechanical.;Biophysics Biomechanics.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 120 p.
  • 总页数 120
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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