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Testing equality of competing risks of patient discontinuation across multiple disease states.

机译：测试跨多种疾病状态的患者停药的竞争风险是否相等。

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摘要

Previous statistical analyses of patient discontinuation in clinical trials have used discontinuation status as the response of interest. These analyses assume that the risks of discontinuation for specific reasons (lack of efficacy, adverse events, other reasons) are independent of each other and that significant risk factors for patient discontinuation have the same effect on the different causes of discontinuation. However, it is possible that the underlying risks of discontinuation for specific reasons could be related and that risk factors for one type of discontinuation could have a very different effect on another type of discontinuation. The competing risks methodology can be applied to test for significant differences between the different risks of discontinuation and determine significant predictors of discontinuation specific to each type of discontinuation. These competing risks methods are applied to real-world clinical trial data in multiple disease states, which have not been applied previously in the analysis of patient discontinuation.
机译：先前在临床试验中对患者停药的统计分析已使用停药状态作为关注的反应。这些分析假设因特定原因（缺乏疗效，不良事件，其他原因）而中止的风险彼此独立，并且患者中止的重要风险因素对不同原因的中止具有相同的影响。但是，可能由于特定原因而终止的潜在风险可能相关，并且一种类型的终止的风险因素可能对另一种类型的终止产生非常不同的影响。竞争风险方法可用于测试停产不同风险之间的显着差异，并确定特定于每种停产类型的停产的重要预测指标。这些竞争风险方法已应用于多种疾病状态下的实际临床试验数据，而以前尚未在患者停药分析中应用这些方法。

著录项

  • 作者

    Nantz, Eric.;

  • 作者单位

    Western Michigan University.;

  • 授予单位 Western Michigan University.;
  • 学科 Statistics.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 155 p.
  • 总页数 155
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 统计学;
  • 关键词

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