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A evaluation of biogenic components of indoor and outdoor particulate matter and indoor settled dust in homes in Baltimore, Maryland.

机译：在马里兰州巴尔的摩市对室内和室外颗粒物以及室内沉降灰尘的生物成分进行评估。

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摘要

Particulate matter (PM) exposure has been widely associated with the increase in morbidity and mortality from cardiovascular and respiratory diseases. PM is a complex mixture containing organic and inorganic carbon, metals, and crustal materials. Biogenic material derived from living organisms is an important component of organic carbon.;Sources of outdoor and indoor PMs are vary. Outdoor PM is generated from vehicle emission, coal and fuel burning, industrial furnaces, and natural process. Indoor PM is from outdoor PM penetration and the additional indoor sources include cooking and human activities such as vacuuming, dusting, and sweeping. Much of the health effects and PM characterization literature has focused on exposures to ambient PM with less research on unique characteristics of indoor PM.;The indoor environment is important exposure source since people spend nearly 80% of their time indoors. Biogenic components are thought to be more prevalent in indoor air. Biogenic compounds are important because they are biologically active and may induce or exacerbate respiratory diseases.;The overall objective of this research is to characterize and compare the biogenic components in indoor and outdoor PM and in indoor settled dust. Biogenic components assessed include total protein, allergens (house dust mite, mouse, cockroach, cat, and dog allergens), ergosterol (a chemical marker of fungal biomass), and endotoxin (a pro-inflammatory agent of gram-negative bacteria). Air and dust samples were collected from ten homes in Baltimore during May--July 2007.;Micro BCA(TM) assay was used for total protein analysis. The Enzyme-Linked Immunosorbent Assay was used for allergen analysis. Ergosterol was analyzed using GC-MS-MS. Limulus Amebocyte Lysate and recombinant Factor C assays were used for endotoxin analyses.;Our findings suggest that biogenic components are generally greater in indoor PM than outdoor. Biogenic components are greater in PM10 than PM2.5. Biogenic components in indoor PM and settled dust are poorly to moderately correlated. Total protein contributes a significant fraction of PM and indoor settled dust mass.;These data support the hypothesis that biogenic materials may be important risk factor for PM toxicity. Research should be conducted to evaluate whether indoor biogenic components are associated with cardiac and respiratory health effects.
机译：颗粒物（PM）暴露与心血管疾病和呼吸道疾病的发病率和死亡率的增加广泛相关。 PM是包含有机和无机碳，金属和地壳材料的复杂混合物。源自生物体的生物原料是有机碳的重要组成部分。室外和室内PM的来源各不相同。室外PM是由车辆排放，燃煤和燃料燃烧，工业炉以及自然过程产生的。室内PM来自室外PM，其他室内来源包括烹饪和人类活动，例如吸尘，除尘和清扫。许多健康影响和PM表征文献都将注意力集中在暴露于环境PM上，而对室内PM的独特特征的研究却很少。室内环境是重要的暴露源，因为人们将近80％的时间都花在室内。人们认为，生物成分在室内空气中更为普遍。生物化合物很重要，因为它们具有生物活性，并且可能诱发或加剧呼吸系统疾病。这项研究的总体目标是表征和比较室内外PM和室内沉降粉尘中的生物成分。评估的生物成分包括总蛋白，过敏原（屋尘螨，小鼠，蟑螂，猫和狗的过敏原），麦角固醇（真菌生物质的化学标记）和内毒素（革兰氏阴性细菌的促炎剂）。在2007年5月至7月期间，从巴尔的摩的10个家庭中收集了空气和灰尘样品。MicroBCA（TM）分析用于总蛋白分析。酶联免疫吸附测定用于过敏原分析。使用GC-MS-MS分析麦角固醇。变形细胞溶血产物和重组C因子分析用于内毒素分析。;我们的发现表明，室内PM中的生物成分通常比室外更大。 PM10中的生物成分大于PM2.5。室内PM和沉降粉尘中的生物成分之间的相关性很差。总蛋白质占PM和室内沉降尘埃的大部分。这些数据支持以下假设：生物材料可能是PM毒性的重要危险因素。应该进行研究以评估室内的生物成分是否与心脏和呼吸健康影响有关。

著录项

  • 作者

    Taenkhum, Kannika.;

  • 作者单位

    The Johns Hopkins University.;

  • 授予单位 The Johns Hopkins University.;
  • 学科 Health Sciences Public Health.;Environmental Sciences.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 198 p.
  • 总页数 198
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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