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Binding and internalization of glucuronoxylomannan, the major capsular polysaccharide of Cryptococcus neoformans, by murine peritoneal macrophages.

机译：鼠腹膜巨噬细胞对葡糖醛酸氧甘露聚糖（新隐球菌的主要荚膜多糖）的结合和内在化。

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摘要

Cryptococcus neoformans (C. neoformans) infection is of particular importance in modern medicine. C. neoformans is an encapsulated fungus which largely causes opportunistic infections, especially in AIDS or other immunocompromised patients. Due to a strong tropism for the central neural system, C. neoformans is the most common cause of fungal meningoencephalitis. Prior to the implementation of HAART (highly active antiretroviral therapy), up to 5-10% of US patients with AIDS developed cryptococcosis. In humans, the encapsulated yeast C. neoformans is transmitted by inhalation into the alveolar spaces and causes severe life-threatening pneumonia, meningitis, as well as disease in other organ diseases (cryptococcosis). Furthermore, cryptococcosis is a worldwide disease.;The polysaccharide capsule of C. neoformans, the major virulence factor, is composed chiefly of glucuronoxylomannan (GXM) and two minor constituents, galactoxylomannan (GalXM) and mannoprotein (MP). The capsule's interactions with the systems of innate and adaptive immunity modulate the host immune reaction against C. neoformans infection.;With the emerging importance of protective immune responses mediated by innate and adaptive immunity, the regulation and molecular mechanisms during C. neoformans infection or pathogenesis have begun to unfold.;The two main foci of attention in this study of C. neoformans are as follows: (1) Host immune reactions against C. neoformans infection (Chapter 1); (2) Binding and internalization of glucuronoxylomannan (GXM), the major capsular polysaccharide of C. neoformans, by murine peritoneal macrophages (Chapter 2).;Chapter 1 provides an overview of the nature of GXM or C. neoformans and recent advances regarding the interaction of the host immune system with GXM or C. neoformans that include the Th1-dominated response and complement- and antibody-mediated rapid anti-GXM capsular host defense reactions. Chapter 2 describes the central research aim, which is to examine selected cellular mechanisms for binding and uptake of GXM by murine peritoneal macrophages. I hope that the information from Chapter 1 and Chapter 2 may contribute to an understanding of how to facilitate the host response against C. neoformans infection and yield new insights into future immunomodulatory strategies for the treatment of C. neoformans infection.
机译：新型隐球菌（C. neoformans）感染在现代医学中尤为重要。新型梭状芽胞杆菌是一种包囊真菌，在很大程度上引起机会性感染，尤其是在艾滋病或其他免疫功能低下的患者中。由于中枢神经系统的强烈嗜性，新孢子虫是真菌性脑膜脑炎的最常见原因。在实施HAART（高效抗逆转录病毒疗法）之前，美国多达5-10％的艾滋病患者发展为隐球菌病。在人类中，封装的酵母新孢梭菌通过吸入传播到肺泡腔内，并导致严重的威胁生命的肺炎，脑膜炎以及其他器官疾病（隐球菌病）。此外，隐球菌病是一种世界性疾病。新形成梭菌的多糖荚膜是主要的致病因子，主要由葡糖醛酸甘露聚糖（GXM）和两个次要成分半乳糖氧基甘露聚糖（GalXM）和甘露糖蛋白（MP）组成。胶囊与先天性和适应性免疫系统的相互作用调节了宿主抵抗新孢子虫感染的免疫反应。随着先天性和适应性免疫介导的保护性免疫应答的重要性日益显着，新孢子虫感染或发病机理中的调节和分子机制本研究对新孢子虫的关注的两个主要重点如下：（1）宿主对新孢子虫感染的免疫反应（第1章）； （2）鼠腹膜巨噬细胞对葡糖新葡聚糖的主要荚膜多糖葡糖醛酸甘露聚糖（GXM）的结合和内在化（第2章）;第1章概述了GXM或新葡聚糖C.neoformans的性质以及有关其的最新进展宿主免疫系统与GXM或C.neoformans的相互作用，包括Th1为主的反应以及补体和抗体介导的快速抗GXM荚膜宿主防御反应。第2章介绍了主要研究目标，该研究目的是研究通过小鼠腹膜巨噬细胞结合和摄取GXM的选定细胞机制。我希望第1章和第2章中的信息可能有助于理解如何促进宿主应对新福寿菌的感染，并为治疗新福寿菌感染的未来免疫调节策略提供新的见解。

著录项

  • 作者

    Chang, Zong-Liang.;

  • 作者单位

    University of Nevada, Reno.;

  • 授予单位 University of Nevada, Reno.;
  • 学科 Biology Microbiology.
  • 学位 M.S.
  • 年度 2009
  • 页码 57 p.
  • 总页数 57
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;
  • 关键词

  • 入库时间 2022-08-17 11:38:28

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