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首页> 外文学位 >Characterizations of novel mechanisms for tube size control in Drosophila melanogaster.
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Characterizations of novel mechanisms for tube size control in Drosophila melanogaster.

机译：果蝇管大小控制的新机制的表征。

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摘要

Epithelial and endothelial tubes are fundamental components of various organs such as the lung, kidney and the vascular system. Proper size and shape of these tubes are crucial for the organ's function and any deviation from the correct size or shape result in diseases. The Drosophila trachea system is an excellent model system to study the mechanisms that control tube formation as it undergoes highly regulated tube size changes during development and is easily accessible. Previously, eight genes were identified as "tube expansion genes". Identification and characterization of the majority of the genes showed they are components of the insect septate junctions. Mutations in these genes cause abnormal length and diameter of the trachea and compromise the paracellular barrier function of the septate junctions.;Here I describe the work done to identify and characterize one of those eight genes termed convoluted. Flies mutated for convoluted have a severely defected trachea. Contrary to components of the septate junctions previously identified, it does not compromise the paracellular barrier. Cloning and further investigation of this gene reveals a surprising new pathway for tube size control.;In addition this work sheds some light on two known components of the septate junction complex required for proper tube size control. These proteins, Megatrachea and Sinuous, are members of the claudin family of proteins found in both mammals and flies.
机译：上皮和内皮管是诸如肺，肾和血管系统的各种器官的基本组成部分。这些管的正确尺寸和形状对于器官功能至关重要，任何偏离正确尺寸或形状的都将导致疾病。果蝇气管系统是一个优秀的模型系统，可以研究控制管形成的机制，因为它在开发过程中会受到高度调节的管尺寸变化，并且易于使用。以前，八个基因被鉴定为“管扩增基因”。大多数基因的鉴定和表征表明，它们是昆虫分隔连接的组成部分。这些基因中的突变会导致气管的长度和直径异常，并损害分隔连接的细胞旁屏障功能。在这里，我描述了鉴定和表征这8个被卷积的基因之一的工作。突变而卷曲的果蝇气管严重缺损。与先前确定的分隔连接的组成部分相反，它不会破坏细胞旁屏障。对该基因的克隆和进一步研究揭示了令人惊讶的管尺寸控制新途径。此外，这项工作为正确控制管尺寸所需的分隔键连接复合物的两个已知成分提供了一些启示。这些蛋白质，即兆气管和Sinuous，是在哺乳动物和果蝇中都发现的claudin蛋白质家族的成员。

著录项

  • 作者

    Swanson, Lianna.;

  • 作者单位

    Northwestern University.;

  • 授予单位 Northwestern University.;
  • 学科 Biology Genetics.;Biology Cell.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 143 p.
  • 总页数 143
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 11:38:31

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