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首页> 外文学位 >Creation and in vivo evaluation of a porous electrode for pacing in a coronary vein: An assessment of the potential for improved electrical performance and chronic stability of coronary venous pacing leads.
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Creation and in vivo evaluation of a porous electrode for pacing in a coronary vein: An assessment of the potential for improved electrical performance and chronic stability of coronary venous pacing leads.

机译：用于在冠状静脉内起搏的多孔电极的创建和体内评估：评估改善冠状静脉起搏导线的电性能和长期稳定性的潜力。

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摘要

In this work, a porous electrode was fabricated and evaluated in a chronic animal study on a coronary venous pacing lead in order to assess its potential for mitigating chronic lead dislodgements and reducing the characteristic rise in pacing thresholds after implant, both of which being important issues that impact safety and efficacy of implanted cardiac resynchronization therapy systems. Eight test leads were assembled with a porous tip electrode with an average pore size of approximately 30 mum, created via a novel fabrication method, and eight control leads were assembled with a standard solid tip electrode design. Both groups were created without steroid-eluting collars and without a capacitive coating on the tip electrodes in order to isolate the affects of electrode porosity. Leads were implanted in canines, and electrical data and x-rays of lead position were taken regularly throughout the 60-day study. Tissue histology was performed for each lead.;Significantly lower (p0.05) mean rise in pacing threshold after implant was observed at day 3 and day 21 for the test group leads (with porous electrodes) as compared to the control group leads. Despite the higher surface area of the porous tip electrodes, pacing impedance was not statistically different between the groups throughout the study, a result likely due to decreased chronic inflammatory response at the surface of porous electrodes. The test group had no lead retractions after day 3 as determined by inspection of x-ray radiographs, while 3-6 (of 8) control group leads retracted after day 3, a result likely due to anchoring of the lead tip due to observed tissue growth into porous electrodes. Mean fibrous capsule thickness at pre-defined measurement points on the tip electrode was not statistically different between the groups, which correlates with the nearly equal mean pacing thresholds for the groups at day 60. The lack of lead retractions for the test groups leads after day 3 is a promising result which should be investigated further, along with investigations of lead extraction force and further electrical data evaluations, using larger sample sizes and more challenging implant conditions.
机译：在这项工作中，制造了多孔电极，并在一项长期动物研究中对冠状静脉起搏导线进行了评估，以评估其缓解慢性铅移位和降低植入后起搏阈值特征上升的潜力，这两个都是重要问题影响植入式心脏再同步治疗系统的安全性和有效性。通过新颖的制造方法将八根测试引线与平均孔径约为30微米的多孔尖端电极组装在一起，并以标准的实心尖端电极设计组装八根对照引线。两组都是在没有类固醇洗脱环的情况下创建的，在尖端电极上也没有电容性涂层，以便隔离电极孔隙率的影响。在60天的研究过程中，定期将铅植入犬类，并定期获取电子数据和铅位置的X射线照片。对每根导线进行组织组织学检查；与对照组导线相比，在测试组导线（带有多孔电极）的第3天和第21天观察到植入后起搏阈值的平均升高显着较低（p <0.05）。尽管多孔尖端电极的表面积较大，但在整个研究中，各组之间的起搏阻抗在统计学上没有差异，这可能是由于多孔电极表面的慢性炎症反应减少所致。根据X射线照片的检查，测试组在第3天后无铅缩回，而第3天后，有3-6（8个）对照组中的铅回缩，这可能是由于观察到的组织导致了尖端的锚固生长成多孔电极。各组之间尖端电极上预先定义的测量点处的平均纤维囊厚度在统计学上无差异，这与第60天时各组的几乎平均起搏阈值相关。图3是一个有希望的结果，应使用更大的样本量和更具挑战性的植入条件，对铅提取力的研究以及进一步的电气数据评估进行进一步研究。

著录项

  • 作者

    Koop, Brendan Early.;

  • 作者单位

    University of Minnesota.;

  • 授予单位 University of Minnesota.;
  • 学科 Engineering Biomedical.;Engineering Mechanical.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 200 p.
  • 总页数 200
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;机械、仪表工业;
  • 关键词

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