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Environmental and immunologic cofactors for the risk of classic Kaposi sarcoma in Sicily.

机译：西西里经典卡波西肉瘤风险的环境和免疫辅助因子。

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摘要

Background. Cofactors for classic Kaposi sarcoma (KS) are unclear and environmental and immunologic factors have been postulated. Using a case-control study in Sicily we examined the relationships between volcanic soil exposure, T-helper (Th) immune shift and classic KS in Sicily.;Methods. Histologically confirmed KS cases were identified through surveillance of Sicily's pathology laboratories. Population controls were selected using two-stage cluster sample design and KSHV seropositivity was determined for all subjects using 4 antibody assays. Classic KS cases (n=141) were compared to KSHV seropositive controls (n=123) on residential exposure to four types of soil, categorized with maps from the European Soil Database and direct surveying. A subset of plasma samples was tested for Epstein-Barr nuclear antigen (EBNA) and viral capsid antigen (VCA) antibodies, and for soluble cluster of differentiation sCD23, sCD26, and sCD30, as surrogate markers of Th1/Th2 immunity. Levels and categories of markers were compared between classic KS cases (n=119) and seropositive controls (n=105) to estimate odds of KS, and between the latter and seronegative controls (n=155) to estimate odds of KSHV seropositivity.;Results. Residents in communities rich in luvisols (iron rich soil) were approximately 2.7-times more likely to have classic KS than those in communities without luvisols. Among those in luvisol rich communities, the risk was elevated with frequent bathing or tap water drinking. Having KS was unrelated to living in communities high in andosols, tephra, or clay soils. EBV antibody and sCD levels did not differ between cases and seropositive controls, or between seropositive and seronegative controls. Low EBNA/high VCA antibody profile was not associated with KS or KSHV seropositivity. Among controls, subjects with the highest level of VCA antibodies were about twice as likely to be KSHV seropositive. EBV antibodies were lower among those with known KS risk factors, i.e.,male sex, nonsmoking, diabetes and cortisone use.;Conclusion. Classic KS in Sicily is associated with living in area with luvisol rich soil, and water as a possible conduit should be investigated. Better methods are needed to assess possible associations of classic KS with Th1/Th2 immunity.
机译：背景。目前尚不清楚经典的卡波济肉瘤（KS）的辅助因子，并且已推测出环境和免疫因素。通过在西西里岛进行的病例对照研究，我们研究了西西里岛火山土壤暴露，T-help（Th）免疫转变与经典KS之间的关系。组织学确诊的KS病例是通过对西西里岛病理实验室的监视鉴定的。使用两阶段群集样本设计选择人群对照，并使用4种抗体测定法确定所有受试者的KSHV血清阳性。将经典KS病例（n = 141）与KSHV血清阳性对照（n = 123）在居民暴露于四种土壤的情况下进行了比较，并根据欧洲土壤数据库的地图和直接调查进行了分类。测试血浆样本的子集的爱泼斯坦-巴尔核抗原（EBNA）和病毒衣壳抗原（VCA）抗体，以及可溶性sCD23，sCD26和sCD30分化簇，作为Th1 / Th2免疫的替代标志物。比较了经典KS病例（n = 119）和血清阳性对照（n = 105）之间标记物的水平和类别，以估计KS的可能性，后者与血清阴性对照（n = 155）之间，比较了KSHV血清阳性的可能性。结果。富含卢维索酚（富含铁的土壤）的社区居民患经典KS的可能性是没有卢维索酚的社区的居民的2.7倍。在富含卢维索的社区中，经常洗澡或喝自来水会增加患病风险。患有KS与生活在高露石，特非拉或粘土的社区无关。 EBV抗体和sCD水平在病例与血清阳性对照之间，血清阳性与血清阴性对照之间没有差异。低EBNA /高VCA抗体谱与KS或KSHV血清阳性无关。在对照组中，VCA抗体水平最高的受试者出现KSHV血清阳性的可能性约为后者的两倍。在已知的KS危险因素（即男性，不吸烟，糖尿病和可的松使用）中，EBV抗体较低。西西里岛的经典KS与居住在富含卢维索的土壤中有关，应该研究将水作为可能的管道。需要更好的方法来评估经典KS与Th1 / Th2免疫的可能关联。

著录项

  • 作者

    Pelser, Colleen.;

  • 作者单位

    University of Maryland, Baltimore.;

  • 授予单位 University of Maryland, Baltimore.;
  • 学科 Health Sciences Epidemiology.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 96 p.
  • 总页数 96
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 地球物理学;
  • 关键词

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