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Enhancing the mechanical properties of a peptide-based hydrogel via covalent crosslinking.

机译：通过共价交联增强基于肽的水凝胶的机械性能。

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摘要

The challenge of developing materials that can emulate the material strength and stability of natural tissues is addressed through the implementation of a strategy to enhance the mechanical properties of a self-assembling peptide-hydrogel. MAX1, a peptide having the sequence VKVKVKVKVDPPTKVKVKVKV-NH 2, has been shown to self-assemble into a beta-sheet-rich structure forming a non-covalently crosslinked fibrillar network. However, at low peptide concentrations and physiological conditions, imparting additional crosslinks in the gel to produce a more rigid network is desirable. Studies were performed where a crosslinking agent, genipin (GP), was added to a 1 wt% MAX1 hydrogel. GP is capable of reacting with primary amines and, thus, can form covalent crosslinks between MAX1 fibrils by reacting with the lysine side-chains and imparting more crosslinks into the material. The effect of the crosslinking agent on beta-sheet formation and the elastic modulus of the MAX1 hydrogels was studied, and enhanced rigidity was observed for hydrogels with GP crosslinkages. Moreover, the time at which GP is added during the peptide folding and self-assembly process was determined to have an effect on the resultant hydrogel formed and the corresponding material properties.
机译：通过实施增强自组装肽-水凝胶机械性能的策略，可以解决开发可模仿天然组织的材料强度和稳定性的材料的挑战。已显示具有序列VKVKVKVKVDPPTKVKVKVKV-NH 2的肽MAX1自组装成富含β-折叠的结构，形成了非共价交联的原纤维网络。但是，在低肽浓度和生理条件下，需要在凝胶中赋予额外的交联以产生更刚性的网络。进行了研究，其中将交联剂，京尼平（GP）添加到1 wt％的MAX1水凝胶中。 GP能够与伯胺反应，因此可通过与赖氨酸侧链反应并在材料中赋予更多交联，在MAX1原纤维之间形成共价交联。研究了交联剂对β-片层形成和MAX1水凝胶弹性模量的影响，并观察到具有GP交联的水凝胶具有增强的刚性。此外，确定在肽折叠和自组装过程中添加GP的时间对形成的所得水凝胶和相应的材料性能有影响。

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