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I. Cytotoxicity and anti-inflammatory activity of polyphenolics. II. Polyphenolics in natural soils.

机译：I.多酚的细胞毒性和抗炎活性。二。天然土壤中的多酚类。

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Phenolic compounds are known for their epidemiological association with reduced risks for certain diseases. We used rabbit peripheral blood mononuclear cells (PBMCs) to examine anti-inflammatory activity and cytotoxicity of nine polyphenolics, representing several classes of tannins. The results from a sandwich ELISA assay for TNF-α showed that anti-inflammatory activity was only observed with apigenin (EC50 1.0 µg/mL), while other compounds either had no affect on TNF-α or increased its production. Our study also showed that tannins interfered with the MTT cell viability assay and that chemical reactivity of tannins was changed upon spontaneous oxidation. In addition to ELISA, we began to use real-time RT-PCR to quantify cytokine mRNAs in lysates of cells that were treated with phenolics. Polyphenolic compounds are also of interest in the management of soils. We have begun developing a new method using a resin trap to quantify the input of polyphenolics into soil.

机译：酚类化合物因其与流行病学联系而闻名，可降低某些疾病的风险。我们使用兔外周血单个核细胞（PBMC）来检查代表多类单宁的9种多酚类药物的抗炎活性和细胞毒性。 TNF-α夹心ELISA分析的结果表明，只有芹菜素（EC50 1.0 µg / mL）才观察到抗炎活性，而其他化合物对TNF-α没有影响或没有增加其产量。我们的研究还表明，单宁会干扰MTT细胞的活力测定，并且自发氧化会改变单宁的化学反应性。除ELISA外，我们还开始使用实时RT-PCR来定量用酚醛树脂处理过的细胞的裂解物中的细胞因子mRNA。多酚化合物在土壤管理中也很重要。我们已经开始开发一种使用树脂捕集器的新方法，以量化多酚类化合物向土壤中的输入。

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作者
Wisman, Kimberly N.;
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Miami University.;

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授予单位 Miami University.;
学科 Chemistry Biochemistry.;Chemistry Pharmaceutical.;Chemistry Organic.
学位 M.S.
年度 2008
页码 97 p.
总页数 97
原文格式 PDF
正文语种 eng
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5. I. The structure activity relationships and cytotoxic activity of analogs of tryprostatin A and B. Preparation of irreversible inhibitors for studies of mechanism of action. II. Pharmacophore/receptor models for the GABA(A)/Bz receptor subtypes. [D] . Zhang, Chunchun. 2004

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7. EVALUATION OF IN VITRO ANTI-INFLAMMATORY, ANTI-DIABETIC AND ANTI-LIPOGENIC ACTIVITY OF NATURAL POLYPHENOLIC EXTRACTS AND THEIR PURE CONSTITUENTS [O] . Pragati Nahar -1

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8. Plutonium Behavior in the Soil/Water Environment. Part I. Sorption of Plutonium by Soils. Part II. Selected Chemical and Physical Characteristics of Aqueous Plutonium and Their Effects on the Sorption of Plutonium by Soils [R] . Miner, F. J., Evans, P. A., Polzer, W. L. 1982

机译：土壤/水环境中的钚行为。第一部分土壤对钚的吸附。第二部分。钚水溶液的化学和物理特性及其对土壤吸附钚的影响

I. Cytotoxicity and anti-inflammatory activity of polyphenolics. II. Polyphenolics in natural soils.

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