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首页> 外文学位 >Number processing, visuospatial and emotional cognition in asymptomatic individuals with HIV.
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Number processing, visuospatial and emotional cognition in asymptomatic individuals with HIV.

机译：无症状艾滋病毒感染者的数字处理，视觉空间和情绪认知。

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摘要

Human Immunodeficiency Virus (HIV) is an important focus of clinical and cognitive neuroscience research. Multiple studies have implicated frontostriatal dysfunction in HIV and described a profile of cognitive dysfunction with a focus on executive function and memory. By contrast, remarkably little is known about visuospatial and number processing in HIV, though these capacities are also supported by frontostriatal circuits and their parietal connections. The main goal of the present series of studies was to assess the hypothesis that HIV affects numerical and visuospatial processing in early stages of the disease. Standardized and experimental neuropsychological measures were administered to examine functioning in cognitive domains subserved by the areas of the brain supporting numerical and visuospatial processing. The asymptomatic HIV+ group (n=37) was significantly slower and produced more errors on visuospatial and number processing tasks than the HIV- control group (n=37). Both groups showed a significant correlation between number processing and visuospatial performance. These findings demonstrate the impact of HIV on spatial and numerical cognition early in the disease course and provide evidence for the close functional relation between these domains. A second goal was to examine the effect of emotional dysfunction on visuospatial abilities and other aspects of cognition in HIV. In particular, alexithymia, an impairment of affective and cognitive emotional processing, is often associated with HIV and may reflect direct effects of the virus on the prefrontal and anterior cingulate cortices. Accordingly, the hypothesis was that there would be a correlation between extent of alexithymia and cognitive abilities associated with these brain areas, including working memory and executive function, as well as with visuospatial processing because of frontostriatal-parietal interactions. The results revealed that HIV+ participants were significantly more alexithymic than the HIV- group (n=34/group). The extent of alexithymia and its cognitive component, but not depression, correlated with performance on measures of visuospatial and executive function. This examination of visuospatial, numerical and emotional cognition constituted a multidimensional investigation of brain changes associated with HIV. Taken together, the findings expand our understanding of the impact of HIV on visuospatial cognition in the early stage of the disease.
机译：人类免疫缺陷病毒（HIV）是临床和认知神经科学研究的重要重点。多项研究涉及HIV的前额叶功能障碍，并描述了认知功能障碍的概况，重点是执行功能和记忆。相比之下，对艾滋病病毒的视觉空间和数量处理知之甚少，尽管这些能力还受额窦回路及其顶叶连接的支持。本系列研究的主要目标是评估艾滋病毒影响疾病早期阶段的数值和视觉空间加工的假说。进行了标准化和实验性的神经心理学措施，以检查在支持数字和视觉空间处理的大脑区域所服务的认知域中的功能。无症状的HIV +组（n = 37）比艾滋病毒对照组（n = 37）明显更慢并且在视觉空间和数字处理任务上产生更多的错误。两组均显示数字处理和视觉空间性能之间的显着相关性。这些发现证明了艾滋病毒在疾病过程早期对空间和数字认知的影响，并为这些域之间的紧密功能联系提供了证据。第二个目标是检查情绪障碍对视觉空间能力和HIV认知的其他方面的影响。特别是，情感障碍和情感和认知情感加工的障碍通常与艾滋病毒有关，可能反映出病毒对前额叶和前扣带回皮质的直接作用。因此，假说是，运动障碍的程度和与这些大脑区域相关的认知能力之间存在相关性，包括工作记忆和执行功能，以及由于额窦-顶叶相互作用而引起的视觉空间加工。结果显示，HIV +参与者比HIV-群体（n = 34 /组）明显更缺乏运动能力。智力障碍的程度及其认知成分（而非抑郁）与视觉空间和执行功能的测量指标相关。视觉空间，数字和情感认知的这项检查构成了与HIV相关的大脑变化的多维调查。综上所述，这些发现扩大了我们对艾滋病在疾病早期对视觉空间认知的影响的理解。

著录项

  • 作者

    Bogdanova, Yelena.;

  • 作者单位

    Boston University.;

  • 授予单位 Boston University.;
  • 学科 Biology Neuroscience.;Psychology Clinical.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 108 p.
  • 总页数 108
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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