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Effects of TCM and its Bio-Active Compound 7,4'-Dihydroxyflavone on Gastrointestinal Inflammation

机译:中药及其生物活性化合物7,4'-二羟基黄酮对胃肠道炎症的影响

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摘要

Incidence of inflammatory bowel disease is approximately 10 per 100,000 children in the United States and continues to grow worldwide. Symptoms can significantly impact patient's quality of life and can even lead to depression and anxiety disorders. Current treatments can make conditions manageable, but each have their own adverse long-term effects. Traditional Chinese medicine (TCM) shows great potential in being a complementary and alternative treatment for IBD. A series of two pediatric patients noted significant improvements in gastrointestinal symptoms after two years of TCM treatment. This case series and an additional cohort study also demonstrated the safety of this treatment for long term use through analysis of blood work results. 7,4'-dihydroxyflavone (7,4'-DHF) is a compound in Glycyrrhiza uralensis, an herb in these TCM treatment that demonstrates dual beneficial effects in decreasing endoplasmic reticulum stress and having anti-inflammatory functions. 7,4'-DHF is a promising compound for treatment of IBD.
机译:在美国,炎症性肠病的发病率约为每100,000名儿童10例,并且在全世界范围内还在继续增长。症状会严重影响患者的生活质量,甚至可能导致抑郁和焦虑症。当前的治疗可以使疾病易于控制,但每种治疗都有其不利的长期影响。中药(TCM)在作为IBD的补充和替代治疗方面显示出巨大潜力。一系列两名小儿患者在中医治疗两年后,发现胃肠道症状有了明显改善。该病例系列和其他队列研究还通过对血液工作结果进行分析,证明了该疗法长期使用的安全性。 7,4'-二羟基黄酮(7,4'-DHF)是甘草中的一种化合物,甘草是这些中医治疗方法中的草药,在降低内质网应激和具有消炎功能方面显示出双重有益作用。 7,4'-DHF是用于治疗IBD的有前途的化合物。

著录项

  • 作者单位

    Icahn School of Medicine at Mount Sinai.;

  • 授予单位 Icahn School of Medicine at Mount Sinai.;
  • 学科 Immunology.
  • 学位 M.S.
  • 年度 2018
  • 页码 59 p.
  • 总页数 59
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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