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首页> 外文学位 >Adjoint based treatment planning for brachytherapy: Novel techniques and further developments.
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Adjoint based treatment planning for brachytherapy: Novel techniques and further developments.

机译：近距离治疗的基于伴随的治疗计划：新技术和进一步发展。

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摘要

Treatment planning in brachytherapy involves a solution in the form of an acceptable seed and needle configuration fulfilling the treatment planning goals. The target has to be irradiated with uniform prescribed dose with minimal exposure to the adjacent or embedded organs at risk. The number of potential seed positions to choose from is large. More than one seed configuration can fulfill the treatment planning aims. Treatment planning algorithms based on forward dose calculations are iterative in nature as a seed configuration is evaluated against set criteria or constraints and accepted only when they are met.;Methods based on adjoint transport have been proved to generate acceptable treatment planning solutions both in brachytherapy treatment planning and external beam treatment planning. The brachytherapy treatment planning device using adjoint methodology is a Greedy Heuristic (GH) algorithm that generates a solution non-iteratively. The adjoint sensitivity fields operate as a guidance tool for selecting seed positions with the maximum benefit towards depositing dose in the target and sparing the sensitive structure. The GH algorithm thus selects positions one after another and constructs a treatment plan that is acceptable.;This work investigates the development and utility of at least three innovative treatment planning techniques in brachytherapy and a new adjoint based treatment planning device for High Dose Rate (HDR) multi-catheter interstitial brachytherapy. Techniques for Interstitial implant brachytherapy using more than one seed species, directional sources brachytherapy using the anisotropic 125I source and performing permanent seeds brachytherapy without template guidance are some of the innovative techniques discussed. All new techniques are evaluated taking example of prostate sarcoma. A dose-homogeneity based dwell time optimization for HDR brachytherapy treatment planning device is discussed. The multi-catheter HDR technique is evaluated for an accelerated partial breast irradiation case.
机译：近距离放射治疗中的治疗计划涉及一种可以满足治疗计划目标的可接受的种子和针头配置形式的解决方案。必须以均匀的规定剂量照射靶标，同时尽量避免暴露于处于危险中的相邻或嵌入器官。要选择的潜在种子位置数量很多。一个以上的种子配置可以满足治疗计划的目标。基于前向剂量计算的治疗计划算法本质上是迭代的，因为根据设定的标准或约束条件评估种子配置，并且仅在满足条件时才接受种子配置；已证明基于伴随运输的方法在近距离放射治疗中均可以产生可接受的治疗计划解决方案计划和外部束治疗计划。使用伴随方法的近距离放射治疗计划设备是一种Greedy Heuristic（GH）算法，它可以非迭代地生成解决方案。伴随的灵敏度字段用作选择种子位置的指导工具，从而最大程度地有利于在目标中沉积剂量并节省敏感结构。 GH算法因此一个接一个地选择位置并构建可接受的治疗计划。这项工作研究了近距离放射治疗中至少三种创新治疗计划技术的发展和实用性以及一种用于高剂量率（HDR）的新型基于伴随的治疗计划设备）多导管间质近距离放射疗法。使用多种种子进行间质植入物近距离放射治疗的技术，使用各向异性125I源进行定向源近距离放射治疗以及在没有模板指导的情况下进行永久种子近距离放射治疗是本文讨论的一些创新技术。所有新技术均以前列腺肉瘤为例进行评估。讨论了基于剂量均一性的HDR近距离治疗计划设备的停留时间优化。对于加速的部分乳房照射情况，评估了多导管HDR技术。

著录项

  • 作者

    Chaswal, Vibha.;

  • 作者单位

    The University of Wisconsin - Madison.;

  • 授予单位 The University of Wisconsin - Madison.;
  • 学科 Health Sciences Radiology.;Health Sciences Oncology.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 187 p.
  • 总页数 187
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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