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Comorbidity, body composition and the progression of advanced colorectal cancer.

机译:合并症,身体成分和晚期大肠癌的进展。

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摘要

The purpose of this work was to further understand nutritional status, especially body weight and composition, during colorectal cancer progression. Population-based studies of colorectal cancer patients were conducted using administrative health data (primary and co-morbid diseases, demographics), and computed tomography (CT) imaging (body composition). In cohort 1, administrative health data was used to study comorbidities and nutritional status in 574 colorectal cancer patients referred for chemotherapy. Multivariate Cox regression revealed several comorbidities, performance status and weight loss ≥ 20% predicted survival. In cohort 2, a serial CT image analysis assessed longitudinal body composition changes during the last 12 months preceding death from colorectal cancer (n=34). Body composition changes were typified by exponential increases in liver metastases with concurrent accelerations of muscle and fat loss. These results have the potential to make a difference in how colorectal cancer patients are treated and researched by dietitians, oncologists, and health services researchers.
机译:这项工作的目的是进一步了解大肠癌进展过程中的营养状况,尤其是体重和组成。使用行政管理性健康数据(原发和合并病,人口统计学)和计算机断层扫描(CT)成像(身体成分)进行了大肠癌患者的基于人群的研究。在队列1中,行政健康数据用于研究574接受化疗的大肠癌患者的合并症和营养状况。多元Cox回归显示多种合并症,表现状态和体重减轻≥20%的预测生存率。在队列2中,连续CT图像分析评估了大肠癌死亡前最后12个月内纵向身体成分的变化(n = 34)。身体组成的变化以肝脏转移的指数增加以及肌肉和脂肪的损失同时加速为特征。这些结果可能会改变营养师,肿瘤学家和卫生服务研究人员如何治疗和研究结直肠癌患者。

著录项

  • 作者单位

    University of Alberta (Canada).;

  • 授予单位 University of Alberta (Canada).;
  • 学科 Health Sciences Nutrition.;Health Sciences Oncology.
  • 学位 M.Sc.
  • 年度 2010
  • 页码 127 p.
  • 总页数 127
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

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