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首页> 外文学位 >Studies of cell migration and programmed cell death: characterization and analysis of scattershot, a mutation disrupting germ cell migration and programmed cell death in Drosophila melanogaster.
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Studies of cell migration and programmed cell death: characterization and analysis of scattershot, a mutation disrupting germ cell migration and programmed cell death in Drosophila melanogaster.

机译：细胞迁移和程序性细胞死亡的研究：散点图的表征和分析，果蝇的突变破坏了生殖细胞的迁移和程序性细胞死亡。

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摘要

Cell migration is a process critical to development, wound healing, immune response and defects in this process are the cause of many disease states. Elucidating the molecular mechanisms and signal transduction cascades mediating this process is crucial to the development of new hypotheses as to the causes, implications, and potential treatments of these diseases. In some cases cell survival/cell death decisions are closely linked to cell migration in order to rid the organism of cells that are in excess or are located in inappropriate locations and risk harm to the organism. Drosophila germ cell migration provides an excellent system in which to study the interplay of cell migration and cell death decisions. The migratory movements of these germ cells, from their formation at the posterior pole of the embryo to their incorporation into the gonads, have been well characterized and it is known to involve multiple steps. Along this journey, approximately half of the germ cells that originate at the posterior pole are removed from the embryo by programmed cell death. The G protein-coupled receptor, trapped in endoderm 1 (tre1) , is involved in the migration of the germ cells through the posterior midgut epithelium. The scattershot mutation affects both germ cell migration and programmed death of germ cells. We identify the molecular defect in the scattershot mutation that confirms it as an allele of tre1. Additionally, a reverse genetics screen was employed to identify additional genes involved in Drosophila germ cell migration/programmed cell death processes.
机译：细胞迁移是发育的关键过程，伤口愈合，免疫反应和该过程中的缺陷是许多疾病状态的原因。阐明介导此过程的分子机制和信号转导级联对于新假说的发展至关重要，这些假说涉及这些疾病的原因，含义和潜在治疗方法。在某些情况下，细胞存活/细胞死亡的决定与细胞迁移密切相关，以消除生物体内过多或位于不适当位置的细胞，并对生物造成危害。果蝇生殖细胞迁移提供了一个极好的系统，可在其中研究细胞迁移与细胞死亡决策之间的相互作用。这些生殖细胞的迁移运动，从它们在胚胎后极的形成到它们掺入性腺中，已经得到了很好的表征，并且已知它涉及多个步骤。在此过程中，大约一半起源于后极的生殖细胞通过程序性细胞死亡从胚胎中去除。内胚层1（tre1）中捕获的G蛋白偶联受体参与生殖细胞通过中肠后上皮的迁移。散布突变影响生殖细胞迁移和生殖细胞程序性死亡。我们确定了散点突变中的分子缺陷，证实其为tre1等位基因。另外，采用反向遗传学筛选来鉴定与果蝇生殖细胞迁移/程序性细胞死亡过程有关的其他基因。

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  • 作者

    Kamps, Angela Renee.;

  • 作者单位

    Iowa State University.;

  • 授予单位 Iowa State University.;
  • 学科 Genetics.;Molecular biology.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 108 p.
  • 总页数 108
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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