Objective:To analyze the survival time and main influencing factors on the death from silicosis in a copper mine. Methods; Retrospective analysis was carried out in 48 deaths from silicosis in a copper'mine regarding the clinical history and report of the occupational disease to calculate the age of exposure to dust, duration of exposure, attack age and post-pneumoconiosis life span, and Kaplan-Meier survival analysis was undertaken to compare the survival of different groups. Cox proportional hazards regression model was used to estimate the survival time and important influencing factors. Results: Of the 48 patients, mean age of exposure to dust was (24. 4 ± 6. 0); mean duration of exposure, (22. 5 ± 8.7)years; mean attack age, (62.6 ± 11.1) and mean survival time(95 % CI) ,(14.0 ±2.4) years. No significant difference was found between different stages of disease on death of silicosis, associated pulmonary tuberculosis and lung cancer, smoking history and survival rate ( P > 0. 05 ) . Conclusion; Survival analysis can be useful statistics to deal with the death from silicosis, and survival of silicosis patients is associated with a variety of influencing factors. Besides, the parameters, including duration of exposure, age of exposure to dust and attack age, may be sufficiently to estimate the progression and outcomes of prevention of this disease.%目的:应用生存分析方法研究矽肺死亡病例的生存时间和相关影响因素.方法:收集某铜矿企业48例矽肺病死亡患者的病历资料和职业病报告,建立数据库,计算接尘年龄、接尘工龄、发病年龄、生存时间等,采用Kaplan-Meier法描述不同组别矽肺死亡病例的生存率,运用COX比例风险模型分析矽肺死亡病例生存时间影响因素.结果:48例肺病死亡患者平均接尘年龄为(24.4±6.0)岁,平均接尘工龄(22.5±8.7)年,平均发病年龄(62.6±11.1)岁；生存时间中位数(P25,P75)为14.0(7,22)年；死亡时最高矽肺分期、是否合并肺结核、是否合并肺癌、是否有吸烟史之间生存率的比较,差异没有显著意义(P＞0.05)；COX回归结果表明接尘年龄、发病年龄是影响生存时间的重要因素.结论:生存分析方法能有效地处理矽肺死亡病例生存资料；尘肺患者的生存时间受多种因素的影响,接尘工龄、接尘年龄、发病年龄等指标是综合分析尘肺发展规律,评价防治效果的重要参数.
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