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《生物化学与生物物理学报：英文版》
>Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion
Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is suggested to be a long (～7 kb) non-coding RNA. MALAT1 is overexpressed in many human carci- nomas, but its function remains unknown. To investigate the role of MALAT1 in human cervical cancer pro-gression, we designed and used short hairpin RNA to inhibit MALAT1 expression in CaSki cells and validated its effect on cell proliferation and invasion.Changes in gene expression were analyzed by reverse transcriptasepolymerase chain reaction. Our data demonstrated that MALAT1 was involved in cervical cancer cell growth, cell cycle progression, and invasion through the regulation of gene expression, such as caspase-3, -8, Bax, Bcl-2, and BclxL, suggesting that MALAT1 could have important implications in cervical cancer biology. Our findings illustrate the biological significance of MALAT1 in cervical cancer progression and provide novel evidence that MALAT1 may serve as a therapeutic target in the prevention of human cervical cancer.
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