Amphiphilic poly（ε-caprolactone）-block-poly（N-vinyl pyrrolidone）（PCL-b-PNVP） copolymer was synthesized by nitroxide-mediated radical polymerization of N-vinyl pyrrolidione（NVP） at the media-tion of PCL with terminated-nitroxide radical group（PCL-T）;PCL-T has been prepared by the ring-opening polymerization of ε-CL with 4-hydroxy-2,2,6,6-tetramethyl-piperidinooxy（HTEMPO） as initiator.The hy-drogen nuclear magnetic resonance（1H NMR）,electron spin resonance（ESR）,fourier transform infrared spectroscopy（FTIR） and gel permeation chromatography（GPC） were employed to characterize the structure of the polymers.The self-assembly behavior of the copolymers in aqueous media was studied by fluores-cence spectra,dynamic light scanning（DLS） and transmission electron microscope（TEM）.The results showed that the well-defined PCL-b-PNVP copolymer could be synthesized by combination of ring-opening polymerization and nitroxide-mediated radical polymerization,and the obtained copolymer could be self-assembled into well-dispersed core-shell spherical micelles with a size of 100 nm in aqueous solution.Moreover,the copolymer displayed good biocompatibility and could be acted as the hydrophobic drug car-rier.%以4-羟基-2,2,4,4-四甲基哌啶氮氧自由基为引发剂,通过ε-己内酯（ε-CL）的开环聚合反应,合成氮氧稳定自由基为末端基的聚己内酯（PCL-T）;在其＂介调＂下,进行乙烯基吡咯烷酮（NVP）的氮氧稳定自由基聚合（NMP）,得到结构规整聚己内酯和聚乙烯吡咯烷酮两亲性的嵌段共聚物（PCL-b-PNVP）.通过核磁共振氢谱（1H NMR）、红外光谱（FTIR）、电子自旋共振（ESR）和凝胶渗透色谱（GPC）对聚合物的结构进行了表征.利用荧光光谱、动态光散射（DLS）、透射电镜（TEM）等手段分析共聚物自组装行为.结果表明,在聚己内酯大分子氮氧自由基＂介调＂下,合成了结构规整的PCL-b-PNVP共聚物,该共聚物在水中可自组装成粒径100 nm左右的核壳结构球形胶束;且共聚物表现出良好的生物相容性,可作为疏水性药物的载体材料.
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