Growing actin networks regulated by obstacle size and shape

Bo Gong; Ji Lin; Jin Qian

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Growing actin networks regulated by obstacle size and shape

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Growing actin networks provide the driving force for the motility of cells and intracellular pathogens. Based on the molecular-level processes of actin polymerization, branching, capping, and depolymerization, we have devel-oped a modeling framework to simulate the stochastic and cooperative behaviors of growing actin networks in pro-pelling obstacles, with an emphasis on the size and shape effects on work capacity and filament orientation in the grow-ing process. Our results show that the characteristic size of obstacles changes the protrusion power per unit length, with-out influencing the orientation distribution of actin filaments in growing networks. In contrast, the geometry of obstacles has a profound effect on filament patterning, which influ-ences the orientation of filaments differently when the drag coefficient of environment is small, intermediate, or large. We also discuss the role of various parameters, such as the aspect ratio of obstacles, branching rate, and capping rate, in affecting the protrusion power of network growth.

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《力学学报：英文版》 |2017年第002期|222-233|共12页
作者
Bo Gong; Ji Lin; Jin Qian;
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Department of Engineering Mechanics, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Zhejiang University, Hangzhou 310027, China;

Department of Engineering Mechanics, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Zhejiang University, Hangzhou 310027, China;

Department of Engineering Mechanics, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Zhejiang University, Hangzhou 310027, China;

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Growing actin networks regulated by obstacle size and shape

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