埃及伊蚊和白纹伊蚊是传播登革病毒(Dengue viruses)的主要媒介,通过一次感染血餐,登革病毒被蚊摄取,病毒首先感染蚊中肠组织,病毒越过蚊中肠到达蚊其它组织,包括涎腺.当感染病毒的蚊再次叮吸另一健康人血时,将涎腺中病毒传播给下一个人.蚊利用它的天然免疫系统抗登革病毒而使其"不发病",并能生存传播这种病毒.蚊抗登革病毒天然免疫主要涉及血细胞、Toll、JAK-STAT、RNAi通道等.本文就蚊抗登革病毒天然免疫效应做了综述.%The Aedes aegypti and Ae. albopictus mosquito is largely responsible for the transmission of dengue viruses that cause disease in humans. The virus is taken up with an infected blood meal from which it will first infect the mosquito gut tissue. From the gut it will migrate to other parts of the mosquito, including the salivary glands, from where it can be transmitted to another human upon a second blood meal. The mosquito utilizes its innate immune system to control dengue virus infection. Infection with the virus will result in the activation of mosquito immune responses that are mainly controlled by the Toll, JAK-STAT pathway. These responses entail antiviral activities that limit infection with the virus. The Mosquito's RNA Interference Pathway have also take part into mosquito innate immunity anti-dengues virus.
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