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首页> 中文期刊> 《药学学报：英文版》 >Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment

Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment

         
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摘要

Taking inspiration from nature, the biomimetic concept has been integrated into drug delivery systems in cancer therapy. Disguised with cell membranes, the nanoparticles can acquire various functions of natural cells. The cell membrane-coating technology has pushed the limits of common nano-systems(fast elimination in circulation) to more effectively navigate within the body. Moreover, because of the various functional molecules on the surface, cell membrane-based nanoparticles(CMBNPs) are capable of interacting with the complex biological microenvironment of the tumor. Various sources of cell membranes have been explored to camouflage CMBNPs and different tumor-targeting strategies have been developed to enhance the anti-tumor drug delivery therapy. In this review article we highlight the most recent advances in CMBNP-based cancer targeting systems and address the challenges and opportunities in this field.

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  • 来源
    《药学学报：英文版》 |2018年第1期|P.14-22|共9页
  • 作者

    Ruixiang Li; Yuwei He; Shuya Zhang; Jing Qin; Jianxin Wang;

  • 作者单位

    Department of Pharmaceutics, School of Pharmacy, Fudan University;

    Key Laboratory of Smart Drug Delivery, Ministry of Education;

    Institute of Materia Medica, Academy of Chinese and Western Integrative Medicine, Fudan University;

    Department of Pharmaceutics, School of Pharmacy, Fudan University;

    Key Laboratory of Smart Drug Delivery, Ministry of Education;

    Institute of Materia Medica, Academy of Chinese and Western Integrative Medicine, Fudan University;

    Department of Pharmaceutics, School of Pharmacy, Fudan University;

    Key Laboratory of Smart Drug Delivery, Ministry of Education;

    Institute of Materia Medica, Academy of Chinese and Western Integrative Medicine, Fudan University;

    Department of Pharmaceutics, School of Pharmacy, Fudan University;

    Key Laboratory of Smart Drug Delivery, Ministry of Education;

    Institute of Materia Medica, Academy of Chinese and Western Integrative Medicine, Fudan University;

    Department of Pharmaceutics, School of Pharmacy, Fudan University;

    Key Laboratory of Smart Drug Delivery, Ministry of Education;

    Institute of Materia Medica, Academy of Chinese and Western Integrative Medicine, Fudan University;

  • 原文格式 PDF
  • 正文语种 CHI
  • 中图分类 制剂学;
  • 关键词

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