Design,synthesis,and biological evaluation of novel tetrahydroprotoberberine derivatives(THPBs) as proprotein convertase subtilisin/kexin type 9(PCSK9)modulators for the treatment of hyperlipidemia

著录项

• 来源
  《药学学报：英文版》 |2019年第6期|P.1216-1230|共15页
• 作者

  Chenglin Wu; Cong Xi; Junhua Tong; Jing Zhao; Hualiang Jiang; Jiang Wang; Yiping Wang; Hong Liu;

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• 作者单位

  State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 ChinaSchool of Pharmacy China Pharmaceutical University Nanjing 210009 China;

  State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 ChinaUniversity of Chinese Academy of Sciences Beijing 100049 China;

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• 原文格式 PDF
• 正文语种 chi
• 中图分类 中药实验药理;
• 关键词

  PCSK9; Tetrahydroprotoberberine derivatives; Low-density lipoprotein cholesterol; Lipid-lowering; PCSK9 expression; Low-density lipoprotein receptor; Total cholesterol; Hyperlipidemia hamster;

  机译：PCSK9;四氢小ber碱衍生物;低密度脂蛋白胆固醇;降脂;PCSK9表达;低密度脂蛋白受体;总胆固醇高脂血症仓鼠;