Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy:opportunities,challenges, and future development

Yixin Sun; Dongyang Zhao; Gang Wang; Yang Wang; Linlin Cao; Jin Sun; Qikun Jiang; Zhonggui He

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Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy:opportunities,challenges, and future development

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Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy(PDT) suffers from the undesirable impediment of local hypoxia in tumors. Moreover, PDT could further worsen hypoxia. Therefore, developing effective strategies for manipulating hypoxia and improving the effectiveness of PDT has been a focus on antitumor treatment. In this review, the mechanism and relationship of tumor hypoxia and PDT are discussed.Moreover, we highlight recent trends in the field of nanomedicines to modulate hypoxia for enhancing PDT, such as oxygen supply systems, down-regulation of oxygen consumption and hypoxia utilization.Finally, the opportunities and challenges are put forward to facilitate the development and clinical transformation of PDT.

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《药学学报：英文版》 |2020年第8期|P.1382-1396|共15页
作者
Yixin Sun; Dongyang Zhao; Gang Wang; Yang Wang; Linlin Cao; Jin Sun; Qikun Jiang; Zhonggui He;
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作者单位

Wuya College of Innovation Shenyang Pharmaceutical University Shenyang 110016 China;

Wuya College of Innovation Shenyang Pharmaceutical University Shenyang 110016 China;

School of Pharmacy Guangxi University of Chinese Medicine Nanning 530200 China;

School of Pharmacy Guangxi University of Chinese Medicine Nanning 530200 China;

Department of Pharmaceutics the Second Hospital of Dalian Medical University Dalian 116023 China;

Wuya College of Innovation Shenyang Pharmaceutical University Shenyang 110016 China;

Wuya College of Innovation Shenyang Pharmaceutical University Shenyang 110016 China;

Wuya College of Innovation Shenyang Pharmaceutical University Shenyang 110016 China;

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原文格式 PDF
正文语种 chi
中图分类肿瘤治疗学;
关键词
medicines; Oxygen; challenges;

机译：药物;氧气;挑战;

Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy:opportunities,challenges, and future development

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