Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model

De-gang YU; Hui-feng DING; Yuan-qing MAO; Ming LIU; Bo YU; Xin ZHAO; Xiao-qing WANG

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Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model

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Aim:To investigate whether strontium ranelate (SR),a new antiosteoporotic agent,could attenuate cartilage degeneration and subchondral bone remodeling in osteoarthritis (OA).Methods:Medial meniscal tear (MMT) operation was performed in adult SD rats to induce OA.SR (625 or 1800 mg·kg-1.d-1) was administered via gavage for 3 or 6 weeks.After the animals were sacrificed,articular cartilage degeneration was evaluated using toluidine blue O staining,SOX9 immunohistochemistry and TUNEL assay.The changes in microarchitecture indices and tissue mineral density (TMD),chemical composition (mineral-to-collagen ratio),and intrinsic mechanical properties of the subchondral bones were measured using micro-CT scanning,confocal Raman microspectroscopy and nanoindentation testing,respectively.Results:The high-dose SR significantly attenuated cartilage matrix and chondrocyte loss at 6 weeks,and decreased chondrocyte apoptosis,improved the expression of SOX9,a critical transcription factor responsible for the expression of anabolic genes type Ⅱ collagen and aggrecan,at both 3 and 6 weeks.Meanwhile,the high-dose SR also significantly attenuated the subchondral bone remodeling at both 3 and 6 weeks,as shown by the improved microarchitecture indices,TMD,mineral-to-collagen ratio and intrinsic mechanical properties.In contrast,the low-dose SR did not significantly change all the detection indices of cartilage and bone at both 3 and 6 weeks.Conclusion:The high-dose SR treatment can reduce articular cartilage degeneration and subchondral bone remodeling in the rat MMT model of OA.

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《中国药理学报：英文版》 |2013年第3期|393-402|共10页
作者
De-gang YU; Hui-feng DING; Yuan-qing MAO; Ming LIU; Bo YU; Xin ZHAO; Xiao-qing WANG;
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Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011,China;

Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011,China;

Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011,China;

Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011,China;

Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji-nan 250014, China;

Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011,China;

Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011,China;

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Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model

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