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Protective effect of ginsenoside Rg1 on glutamate-induced lung injury

机译:人参皂苷Rg1对谷氨酸诱导的肺损伤的保护作用

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摘要

Aim: To examine the possible protective effect of ginsenoside Rg1, an active component of ginseng, on lung injury caused by glutamate in vivo. Methods: The lungs of mice receiving glutamate (0.5 g/kg) and/or ginsenoside Rg1 (0.03 g/kg) via intraperitoneal administration were collected. The indexes of lung wet weight/body weight ratios (LW/BW), lung wet/dry weight ratios (W/D), heart rate (HR),and breathing rate (BR) were determined. The activity of nitric oxide synthase(NOS), xanthine oxidase (XOD), superoxide dismutase (SOD), catalase (CAT), the content of NO, and malondialdehyde in the lung homogenate were measured.Results: Treatment with glutamate for 2 h increased LW/BW, W/D, HR, and BR.These changes were nearly abolished by pretreatment with ginsenoside Rg1 for 30 min before glutamate injection. An analysis of the lung homogenate demon-strated the protective effect as evidenced by the inhibition of NOS (12%) and XOD (50%) inactivity, the enhanced activity of SOD (20%) and CAT (25%).Conclusion: Ginsenoside Rg1 has a potential protective role in lung diseases associated with glutamate toxicity.
机译:目的:探讨人参有效成分人参皂苷Rg1对体内谷氨酸引起的肺损伤的可能保护作用。方法:收集通过腹膜内给药接受谷氨酸(0.5 g / kg)和/或人参皂苷Rg1(0.03 g / kg)的小鼠的肺。确定肺湿重/体重比(LW / BW),肺湿重/干重比(W / D),心率(HR)和呼吸率(BR)的指标。测定了肺匀浆中一氧化氮合酶(NOS),黄嘌呤氧化酶(XOD),超氧化物歧化酶(SOD),过氧化氢酶(CAT)的活性,一氧化氮和丙二醛的含量。结果:谷氨酸处理2 h增加LW / BW,W / D,HR和BR。通过在注射谷氨酸之前用人参皂苷Rg1预处理30分钟,这些变化几乎被消除。对肺匀浆的分析表明具有保护作用,如抑制NOS(12%)和XOD(50%)失活,增强SOD(20%)和CAT(25%)所证明的。结论:人参皂甙Rg1在与谷氨酸毒性有关的肺部疾病中具有潜在的保护作用。

著录项

  • 来源
    《中国药理学报:英文版》 |2007年第3期|392-397|共6页
  • 作者单位

    Departments of Physiology,Xiangya medical school,Xiangya Hospital,Central South University,Changsha 410078,China;

    Departments of Physiology,Xiangya medical school,Xiangya Hospital,Central South University,Changsha 410078,China;

    Departments of Physiology,Xiangya medical school,Xiangya Hospital,Central South University,Changsha 410078,China;

    Neonatology,Xiangya Hospital,Central South University,Changsha 410078,China;

    Departments of Physiology,Xiangya medical school,Xiangya Hospital,Central South University,Changsha 410078,China;

    Departments of Physiology,Xiangya medical school,Xiangya Hospital,Central South University,Changsha 410078,China;

    Departments of Physiology,Xiangya medical school,Xiangya Hospital,Central South University,Changsha 410078,China;

    Neonatology,Xiangya Hospital,Central South University,Changsha 410078,China;

  • 收录信息 中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 药学;
  • 关键词

    ginsenoside Rg1; glutamate; acute lung injury; nitrogen monoxide; reactive oxygen species;

    机译:人参皂苷Rg1;谷氨酸急性肺损伤;一氧化氮;活性氧;
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