Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism

Yin-ye WANG; Zhi-yu TANG; Min DONG; Xiao-yan LIU; Shi-qi PENG

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Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism

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AIM: To observe the oral anti-platelet efficacy and the potential action mechanism of polyaspartoyl L-arginine (PDR), a new L-arginine rich compound. METHODS: Platelet aggregation was conducted by Born's method;bleeding time was determined using tail's bleeding time in mice; platelet adhesion was carried out with glass bottle method; nitric oxide (NO) was tested with Griess' method; and cAMP, thromboxane B2 (TXB2) and 6-keto-PGF1a were assessed with commercial kits. RESULTS: The inhibition by PDR (15-60 mg/kg ig or 10 mg/kg iv) of platelet aggregation induced by adenosine diphosphate (ADP), collagen or thrombin at 1 h after oral administration or at 20 min after iv injection for rats (P<0.01), and its (15 mg/kg, ig) inhibition of ADP-induced platelet aggregation for rabbits during 6 h after administration were observed. PDR (15-60 mg/kg) prolonged the bleeding time of mice (P<0.05) and (30 mg/kg) increased NO concentration in plasma. On the other hand PDR did not change the contents of cAMP in platelet and TXB2 or 6-keto-PGF1a in plasma. CONCLUSION: PDR is a novel, oral effective platelet aggregation inhibitor and its action mechanism possibly related to increasing NO generation.

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《中国药理学报：英文版》 |2004年第4期|469-473|共5页
作者
Yin-ye WANG; Zhi-yu TANG; Min DONG; Xiao-yan LIU; Shi-qi PENG;
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作者单位

Department of Pharmacology,Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China;

Department of Pharmacology,Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China;

Department of Pharmacology,Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China;

Department of Pharmacology,Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China;

Department of Pharmacology,Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China;

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原文格式 PDF
正文语种 chi
中图分类药学;
关键词
platelet aggregation; bleeding time; platelet adhesiveness; polyaspartoyl L-arginine; nitric oxide; cyclic AMP; Thromboxane B2; 6-ketoprostaglandin F1 alpha;

机译：血小板凝集;流血时间;血小板粘附性;聚天冬氨酸L-精氨酸;一氧化氮;环状AMP;血栓烷B2;6-酮罗格列汀F1α;

Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism

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