采用水热合成一锅法制备了聚丙烯酸功能化单分散的La1-xEuxF3纳米颗粒(La1-xEuXF3@PAANPs).利用透射电子显微镜(TEM)、X射线衍射(XRD)、傅里叶变换红外光谱(FTIR)和光致发光光谱(PL)对样品的形貌、结构、组成和荧光性能进行表征.该纳米颗粒平均粒径为(7±3) nm,具有较好的分散性、稳定性与生物相容性.将纳米颗粒与HeLa癌细胞共同孵育,体外成像结果表明材料对HeLa癌细胞显示出低细胞毒性.用水热法制备的La1-xEuxF3@PAA纳米颗粒可以作为光学荧光探针用于细胞成像,在生物医学领域表现出巨大的潜力.%Monodisperse La1-xEuxF3 nanoparticles (NPs) were functionalized by poly(acrylic acid) (PAA) via a one-pot modified hydrothermal method.The morphology,crystal structure,surface groups,and luminescence properties of the as-produced La1-xEuxF3@PAA NPs were characterized by transmission electron microscopy (TEM),X-ray diffraction (XRD),Fourier transform infrared spectroscopy (FTIR),and photoluminescence (PL) spectroscopy.The produced nanoparticles were (7 ± 3) nm in size,water soluble,and buffer stable,with good photostability and biocompatibility.In vitro imaging revealed the low cytotoxicity of the as-synthesized NPs incubated with HeLa cancer cells.Thus,the colloidal La1 xEuxF3@PAA NPs exhibit great potential for use as optical imaging probes in biological applications.
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