随机选取新西兰雌性大白兔20只,他莫昔芬灌胃,对照兔肝脏病理结果得出:单独应用二维超声诊断肝脏弥漫性病变的准确率为77. 78%;应用受试者工作特征曲线( ROC)得出总胆固醇(TC)和甘油三酯(TG)曲线下面积(AUC)分别是0. 792、0. 799;声触诊组织量化技术( VTQ) AUC 为0. 792;VTQ 联合上述指标诊断应用他莫昔芬后兔肝损害AUC为0. 937,明显高于任何单一指标的诊断率( P =0. 003),此方法有望成为临床上乳腺癌患者内分泌治疗后肝损害筛查及评估预后的新标准.%Twenty female New Zealand rabbits were randomly selected and given gavage with tamoxifen. Compared with the pathological results, the accuracy of ultrasonic diagnosis of hepatic lesion was 77. 78%. The area under the receiver operating characteristic curve ( ROC) ( AUC) of total cholesterol ( TC) was 0. 792 and triglyceride ( TG) was 0. 799. The area under the curve of virtual touch tissue quantification VTQ ( AUC) was 0. 792. The AUC of VTQ combined with the above indicators was 0. 937, the rate of diagnosis of hepatic lesion was significantly higher than that of any single indicator (P=0. 003). Therefore, this method is expected to become a new standard for screening and assessing prognosis of liver damage after tamoxifen therapy in clinical breast cancer patients.
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