Objective To explore correlation bwtween age and chemotherapy-induced cognitive impairment ( CICI) in triple negative breast cancer ( TNBC ) patients. Methods Minimum Mental State Examination ( MMSE ) and questionnaires of retrospective memory( RM) and prospective memory( PM) were performed in 90 breast cancer pa-tients with chemotherapy treatment and 90 health controls. All subjects were divided into TNBC group and non-TN-BC group(45 cases for each) . And all subjects were divided into three age group on average ( young and middle-aged group, elderly group) , each age group were consisted with 15 TNBC cases and 15 non-TNBC cases. Results Compared with the healthy controls, MMSE and questionnaires of RM and PM in breast cancer patients with chemotherapy treatment had statistical significance ( P <0. 0001 ) . Linear correlation analysis found that MMSE in breast cancer patients with chemotherapy treatment was negatively correlated with age(r= -0. 675,P<0. 0001), and questionnaires of RM and PM were positively correlated with age(r=0. 500、0. 429,P<0. 0001). MMSE and questionnaires of RM and PM all had statistic significance(P<0. 05) between TNBC group and non-TNBC group. There was statistical significance of MMSE and questionnaires of RM and PM in young and middle-aged group and elderly group(P<0. 0001) in both TNBC group and non-TNBC group. In young-aged group, compared with non-TNBC group, MMSE and questionnaires of RM and PM in TNBC group had statistic significance(P<0. 05). While middle-aged group and elderly group did not see the same results in young-aged group. Logistic regression analysis revealed that TNBC (OR=3. 763,P=0. 005), age (OR=1. 097, P<0. 0001) were the risk factors for CICI of breast cancer. Conclusion Breast cancer patients with chemotherapy treatment all undergo varying degrees of cog-nitive impairment. Compared with non-TNBC patients,TNBC patients have worse cognitive impairment,especially in young-aged patients. TNBC and age are both the risk factors for CICI of breast cancer.%目的 探讨三阴性乳腺癌化疗相关认知障碍(CICI)与年龄的相关性.方法 纳入不同年龄段乳腺癌化疗患者和健康对照组各90例,其中三阴性乳腺癌(三阴组)及非三阴性乳腺癌(非三阴组)各45例,分为青年、中年、老年组各30例,其中三阴组、非三阴组各年龄分组均为15例.分别进行简易精神状态检查表(MMSE)及回顾性记忆(RM)和前瞻性记忆(PM)问卷调查.结果 乳腺癌组与健康对照组MMSE、RM量表、PM量表评分相比差异均有统计学意义(P<0.0001).乳腺癌组中,MMSE评分与年龄呈负相关性(r=-0.675,P<0.0001),RM量表、PM量表评分与年龄呈正相关性(r=0.500、0.429,P<0.0001).三阴组、非三阴组在MMSE、RM量表、PM量表中差异均有统计学意义(P<0.05).三阴组、非三阴组中,其青年组、中年组、老年组3组间MMSE、RM量表、PM量表评分差异均有统计学意义(P<0.0001).在青年组中,三阴组与非三阴组相比,MMSE、RM量表、PM量表评分差异均有统计学意义(P<0.0001).而中、老年组中,三阴组与非三阴组相比,MMSE、PM量表、RM量表评分差异均无统计学意义.多元Logistic回归分析结果显示:三阴性乳腺癌(OR=3.763,P=0.005)、年龄(OR=1.097,P<0.0001)为乳腺癌患者发生认知障碍的危险因素.结论 乳腺癌化疗患者均出现不同程度的认知障碍,与非三阴性乳腺癌患者相比,三阴性乳腺癌患者认知障碍较严重,其差异主要以青年患者为主,同时三阴性乳腺癌与年龄均为乳腺癌CICI的危险因素.
展开▼
