To investigate the changes of drug resistance of pseudomonas aeruginosa ( PA) to common antimicrobial agents in recent 3 years in Anhui province. The average drug resistance rate was 15. 3%, 17. 0% for piperacillin/tazobactam, amikacin respectively, while the average resistance rate was higher for the third generation cephalospo-rin cefotaxime, ceftriaxone and ceftizoxime, which was between 42. 0% and 55. 0%. The average drug resistance rate was 25. 2% for imipenem. The resistance rates for ceftazidime, cefepime, ceftriaxone and ceftizoxime were sig-nificantly increased( P<0. 05 ) . The resistance of PA to the third generation cephalosporin and ciprofloxacin in-creased gradually, close attention should be paid to it in clinical practice.%观察安徽省近3年来临床分离的铜绿假单胞菌( PA)对常用抗菌药物的耐药性变迁情况。 PA对阿米卡星、哌拉西林/他唑巴坦的耐药率平均值为15．3%、17．0%，对亚胺培南的耐药率平均值为25．2%，对三代头孢菌素头孢噻肟、头孢曲松和头孢唑肟的耐药率为42．0%~55．0%；对头孢他啶、头孢吡肟、头孢曲松和头孢唑肟的耐药水平有显著性提高(P<0．05)。 PA对三代头孢菌素的耐药性呈增高趋势，需引起临床重视。
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