目的 评价并比较米诺环素凝胶和派丽奥的缓释性能和临床疗效.方法 将11位患者的22颗患牙随机分为两组:①龈下刮治和根面平整术(SRP)+米诺环素凝胶(实验组);②SRP+派丽奥(对照组),分别在治疗前和治疗后4周检查龈沟出血指数(SBI)、探诊深度(PD)、松动度(MOB)和龈沟液量4项临床指标;在牙周袋内用药后收集患牙龈沟液,测量牙周袋内的药物浓度.结果 治疗后,实验组与对照组各临床指标相比差异无统计学意义;在牙周局部使用米诺环素凝胶后,第1天药物浓度为3.334 mg/L,以后释放速度逐渐下降,到第7天浓度为1.857 mg/L,使用派丽奥后,第1天的浓度为3.341 mg/L,到第7天降至 0.714 mg/L,两种药物均可维持1周的有效药物浓度.结论米诺环素凝胶局部使用后可在牙周袋内缓慢释放,在辅助治疗牙周炎方面与派丽奥有相同的疗效,具有一定的临床应用价值.%To evaluate and compare the controlled-release characteristic and clinical effect of minocycline gel made in the research group and periocline as an adjunctive therapy to scaling and root planning( SRP ) in periodontitis. Methods 22 tooth in 11 patients with moderate to advanced periodontitis were randomly divided into two groups: SRP plus minocycline gel( experimental group ) and SRP plus periocline( control group ). All clinical parameters including sulcus bleeding index ( SBI ), probing depth ( PD ), mobility ( MOB ) and the quantity of gin-gival crevicular fluid were recorded before treatment and 4 weeks after treatment. The drug concentration in perio-dontal pocket was measured by collecting gingival crevicular fluid after drug use. Results All clinical parameters in two groups had no significant difference at 4 weeks after treatment; Two drugs released slowly after using in peri-odontal pocket and the effective drug concentration could maintain for one week. The concentration of minocycline gel was 3. 334 mg/L at the first day and 1. 857 mg/L at the seventh day, while the concentration of periocline fell from 3. 341 mg/L to 0. 714 mg/L. Conclusion Minocyclin gel can release slowly in periodontal pocket and has a similar clinical effect and application value with periocline in the adjunctive therapy of chronic periodontitis.
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