Objective To observe the changes of serum chemerin, adiponectin, CA199 levels among patients with type 2 diabetes who treated by different therapies of acarbose or insulinoid, and to explore the relationship between chemerin, adiponectin, CA199 and glucose and lipid metabolism. Methods Type 2 diabetes patients received acarbose ( group A, n = 30 ), protamine zinc and insulin lispro mixed injection ( 25R ) ( group B, n = 30 ), or short-term subcutaneous insulin aspart pump therapy ( group C, n = 30 ). Clinical data were recorded. Serum chemerin, adiponectin, CA199 levels before and after treatment were measured by enzyme-linked immunosorbent assay ( ELISA ). T Tests, single-factor analysis of variance, Pearson correlation analysis were used for date analysis. Results ① After treatment, the FBG, PBG, HbAlC of the patients in each group decreased( P <0. 01 ); ② The serum chemerin, CA199 levels decreased after treatment, while the serum adiponectin level increased. The differences were significant P < 0. 01 ); ③ The changed levels of adiponectin and fasting plasma glucose in each group were significantly different ( P < 0. 01 ). Conclusion With the decrease of blood glucose level among patients with type 2 diabetes, CA199, chemerin levels decrease and adiponectin level increases, which may be involved in glucose and lipid metabolism.%目的 研究2型糖尿病患者接受阿卡波糖或胰岛素类似物不同方法治疗前后血清chemerin、脂联素、CA199水平的变化情况,探讨三者与糖脂代谢的关系.方法 2型糖尿病患者接受阿卡波糖(A组,n=30)、精蛋白锌重组赖脯胰岛素混合注射液(25R)(B组,n=30)及短期门冬胰岛素皮下泵强化治疗(CSⅡ)(C组,n=30).记录患者临床资料,采用ELISA法检测患者治疗前后血清chemerin 、脂联素、CA199水平并探讨其联系.结果 ①治疗后,各组患者空腹血糖(FBG)、餐后2 h血糖(PBG)及糖化血红蛋白(HbA1C)下降(P<0.01);② 较治疗前,治疗后各组chemerin、CA199降低,脂联素升高,差异有统计学意义(P<0.01);③ 治疗后脂联素升高水平及空腹血糖下降水平组间差异有统计学意义(P<0.01).结论 随着2型糖尿病患者血糖下降,CA199、chemerin水平降低,脂联素水平升高,该变化可能参与糖脂代谢过程.
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