目的 探讨β半乳糖凝集素-3 (Galectin-3)在植入早期小鼠子宫内膜中的表达分布状况及其意义.方法 应用免疫组化SP法检测妊娠1～5 d小鼠子宫内膜Galectin-3的表达情况,并以动情期非妊娠小鼠子宫做对照.结果 小鼠子宫内膜的所有组织中均有Galectin-3表达,主要表达于腺上皮、腔上皮和基质细胞中.随着小鼠妊娠天数的增加,Galectin-3的表达也逐渐增高,在植入窗口期(妊娠4～5 d)达高峰.结论 Galectin-3在妊娠1～5 d小鼠子宫内膜持续表达,提示在小鼠胚泡植入早期,Galectin-3参与了胚泡的植入过程,在胚泡和子宫内膜的识别过程中发挥重要作用.%study the expression and distribution of Galectin-3 and its significance in the mouse en-dometrium during early implantation. Methods Immunohistochemical SP staining method was used to detect the expression of Galectin-3 in mouse endometrium on day 1 ~ 5 of pregnancy and the un-pregnant mouse endometrium ( estrous stage ) were selected as controls. Results Galectin-3 was detected throughout mouse endometrial tissue, especially in glandular epithelial, luminal epithelial and stromal cells. With the increase in the number of days of pregnancy in mice, Galectin-3 expression also gradually increased and reached a peak in the implantation window period ( pregnancy 4 ~ 5 d ). Conclusion Galectin-3 is expressed continuously in mouse endometrium on day 1 ~ 5 of pregnancy. It suggests that Galectin-3 may take part in the process of blastocyst implantation in early blastocyst implantation in mice. Galectin-3 plays an important role in the identification process of the blastocyst and the endometrium.
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