This study reviews information about the most novel ideas and modalities being incorporated into facial and neck cosmetic care. We seek to identify trends and developments within these areas as well as perceptions of plastic surgeons regarding their probable significance, and discussion on how these modalities may impact future practice patterns. It is hypothesized that nano and regenerative technologies are considered the most "hopeful". Emerging invasive and non-invasive modalities utilizing nano and regenerative concepts were reviewed. We intentionally sought to investigate approaches to beautification, including maintenance and reversal of signs of aging, utilizing methods lacking an established level of evidence. This included promising modalities which are currently at the investigational stage. Twelve board-certified plastic surgeons were surveyed regarding the clinical importance of twelve concepts and their expected impact on facial and neck rejuvenation. Scientific and technological creativity in aesthetics is rapidly changing, and the efficacy of innovations and safety margins are improving. Nano and regenerative medicine-based technologies and procedures were ranked most promising for the future of cosmetics. Their potential applications and research were reviewed in the context of surgical and non-surgical modalities in clinical practice. There has been an advent of new approaches to facial and neck aesthetic surgery and tissue care, which is well-beyond just skin care. With this new level of knowledge regarding variability in care responses and indications for procedures on an almost "molecular level", personalized and precise aesthetic surgery and medicine are quickly becoming a reality.
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