酸枣仁皂苷A(JuA)是酸枣仁中皂苷的主要成分.国内外研究表明JuA具有镇静催眠、降压降脂、抗炎、抗缺氧、增强免疫功能以及对心脏的保护等广泛的药理效应.随着药理学研究方法和技术的更新以及神经生物学的发展,JuA的药动学及其具有广泛的药理学作用不断被发现和深入研究.该文旨在对JuA的药动学研究和药理作用的研究进展作一综述,以期对以后的研究有所裨益.%Jujuboside A(JuA) is one of the main components of saponin in Semen Zizyphi Spinosae (SZS) which is a traditional Chinese medicine.Domestic and foreign researches showed that pharmacological effects of JuA lie in sedative and hypnotic,Anti-hypertension,reducing blood lipid,anti-inflammation,oxygen resistance,enhance the immune function,the protection on the heart and so on.With the update of pharmacology research methods and technologies and the development of neurobiology,pharmacokinetics and extensive pharmacological effects of JuA have been found and further study.To be useful for the later research,this paper reviews the research progress on pharmacokinetics and pharmacologic activities of JuA.
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