Objective To investigate the immunoregulatory mechanisms of tea polyphenols on CIA rats.Mesthods The rats were given intradermal injection of collagen and Freund's complete adjuvant to induce arthritis.We recorded the changes of weight,the rat paw vol-ume,the indexes of thymus and spleen in rats.The serum pro-inflammatory cytokines of IL-6 and TNF-αwere assayed by ELISA.Re-sults Compared with the model group,tea polyphenols (200 mg·kg -1 ·d -1 )could obviously reduce the paw swelling rate,the index of thymus and spleen of CIA rats(P <0.05).The serum pro-inflammatory cytokines levels of IL-6 &TNF-αin tea polyphenols group rats were significantly lower than those in the model group(P <0.05).Conclusions Tea polyphenols have a therapeutic effect on CIA rats,the mechanism of which may be related to the regulation of immune system function .%目的：研究茶多酚（tea polyphenols）对胶原性关节炎大鼠的免疫调节作用。方法采用Ⅱ型胶原加弗氏完全佐剂法建立类风湿性关节炎（collagen-induced arthritis，CIA）大鼠模型。记录大鼠体重，测量大鼠足趾容积，测量大鼠胸腺和脾脏指数，酶联免疫法（ELISA）检测大鼠血清促炎因子 IL-6、TNF-α水平。结果与模型组比较，茶多酚（200 mg·kg －1·d －1）可明显降低 CIA 大鼠足趾肿胀率（P ＜0．05）、胸腺和脾脏指数水平（P ＜0．05），茶多酚治疗组大鼠血清促炎因子 IL-6、TNF-α水平明显低于模型组（P ＜0．05）。结论茶多酚对 CIA 大鼠有治疗作用，其作用机制可能与调节大鼠免疫系统功能有关。
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