系统性红斑狼疮（ systemic lupus erythematosus ，SLE）是一种累及多系统多器官的自身免疫性疾病。近年来，随着临床诊治水平的显著提高，患者预后得到明显改善，远期死亡（诊断5年后）原因得到关注。作为SLE远期主要并发症的早发动脉粥粥样硬化，成为近年研究的热点。该文对SLE中早发动脉粥样硬化发病机制的研究进展进行综述。%Systemic lupus erythematosus is an autoimmune disease which may affect nearly every organ .In recently years ,with the pro-gress of clinical treatment ,SLE prognosis has been greatly enhanced ,and the causes of late death (5 years after diagnosis ) are drawing increasing attention .As a major complication ,atherosclerosis has become a hotspot in recent academic community .This review will focus on the recent advances on the mechanisms of premature atherosclerosis in SLE .
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