目的 探讨B型钠尿肽前体(NT-ProBNP)和高敏C反应蛋白(hs-CRP)联合检测对心力衰竭诊断、病情评估和预后判断的价值.方法 测定该院2010年1月-2012年11月103例明确诊断为充血性心力衰竭(CHF)的患者,测定入院时、出院时血浆NT-ProBNP 和血清hs-CRP水平,进行治疗前后对比观察,并随机抽取该院35名健康体检者作对照组比较,随访6月观察患者心脏事件再发生的情况.结果 血浆NT-ProBNP和血清hs-CRP和水平在心衰不同心功能分级组和健康对照组之间差异有统计学意义,心功能越差,其浓度越高(P<0.05);治疗前后比较,差异均也有统计学意义(P<0.05);出院后发生心脏事件组血浆NT-ProBNP 和血清hs-CRP水平浓度明显高于未发生心脏事件组(P<0.05).结论 心衰患者中NT-ProBNP 、hs-CRP明显升高,二者联合检测对心衰诊断、病情评估和预后判断有应用意义.%Objective To observe the value of B-type natriuretic peptide precursor (NT -ProBNP)and high-sensitivity C-eactive protein (hs-CRP)on patients of heart failure in diagnosis , illness evaluation and prognosis through jointed detection . Methods From January 2010 to November 2012,103 cases of CHF patients were measured plasma NT -ProBNP and hs -CRP serum levels on admission and at discharge. Before and after treatment comparison observations were made ,35 health were selected randomly for control. The patients were followed up for 6 months to observe it cardiac events happen again . Results NT-ProBNP and hs -CRP serum and plasma levels in different heart failure cardiac function grading group had statistically significant difference from healthy control group . The poorer heart function , the higher concentration ( P < 0.05 ) ; Before and after treatment, difference had statistical significance ( P < 0.05 ) ; Concentrations of plasma NT -ProBNP and hs -CRP level were significantly higher in cardiac evento after discharge group than those without cardiac event group(P <0.05). Conclusion In heart failure patients NT-proBNP and hs-CRP are significantly higher ,combined detection of which in heart failure patients shows applied significance in diagnosis , illness and prognosis evaluation.
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