Objective To study the condition and analyze the related factors of amiodarone-induced adverse drug reactions( ADR ) in An-hui province. Methods Amiodarone-related ADR reports reported in Anhui province from Jan 1,2005 to Nov 31,2010 were searched, from which a total of 120 qualified amiodarone-induced ADR reports were screened out and analyzed statistically. Results Amiodarone-induced ADR occurred more in males, aged from 40 to 80, most of which were not serious. They were majorly induced by oral administration, and majorly occurred within 1 to 7 days. They might involve multi-organs or systems, and their clinical manifestations were chiefly nausea,vomiting or constipation. Most were relatively mild,and subsided after amiodarone withdrawal. Conclusion Medical staffs should pay much attention to amiodarone -induced ADR,and ADR monitoring should be more strengthened.%目的 调查安徽省胺碘酮致药品不良反应(ADR)情况并分析相关因素.方法 检索安徽省2005年1月1日～2010年11月31日呈报的与胺碘酮相关的ADR报告表,筛选合格报告表120例,进行统计分析.结果 ADR多发生在40～80岁,男性多于女性;以一般不良反应居多.主要由口服途径给药引起,多发生于给药后1～7 d内;可累及多个系统/器官,多为恶心、呕吐或便秘;多数较轻微,停药或/和对症处理后可好转、治愈.结论 医务人员应重视胺碘酮所致ADR,并进一步加强ADR监测.
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