Aim To establish a method for the determination of paracetanol in xiao ' er anfe huang namin granules. Methods The separation was performed on a Eclipse XDB-C18 column , with methanol:water( 40∶60 )as mobile phase at a flow rate of 1. 0 ml · min-1. The detection wavelength was 275 nm and the injection volume was 20μl. Results The linear range of paracetanol was 5. 84 - 58. 4 mg·ml-1( r =0. 999 8 )with average rate of recovery 116. 6％ .and RSD was 1. 46％ . Conclusion The method is convenient, accurate.and reproducible ,which can be a quality control standard of xiao er anfe huang namin granules.%目的 建立小儿氨酚黄那敏颗粒中对乙酰氨基酚的测定方法.方法 采用Eclipse XDB-C18(4.6 mm× 150 mm,5 μm)色谱柱,以甲醇-水(40:60)为流动相,流速1.0 ml·min-1,检测波长275 nm,进样量为20 μl.结果 对乙酰氨基酚在5.84～58.4 mg·L-1(r=0.999 8)内线性良好,平均回收率为116.6%,RSD=1.46%.结论 该法简便快速、重复性好,可用于该制剂的质量控制.
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