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首页> 中文期刊> 《动物与饲料科学：英文版》 >Study on PRRSV Receptor Genes Differential Expression in Lung Tissues in Different Breeds of Pigs after Infecting with HP-PRRSV

Study on PRRSV Receptor Genes Differential Expression in Lung Tissues in Different Breeds of Pigs after Infecting with HP-PRRSV

         
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[Objective] In order to study the susceptibility molecular mechanism of highly pathogenic porcine reproductive and respiratory syndrome virus( HPPRRSV) JXA1 isolate on Tibetan pig,Zangmei pig and Yorkshire pig. [Method]In the study,real-time quantitative RT-PCR method was established to compare and analyze the differential expression of five porcine reproductive and respiratory syndrome virus( PRRSV) receptor genes( HSPG2,SIGLEC1,CD163,VIM and NMMHC-II A) in lung tissues in Tibetan pig,Zangmei pig and Yorkshire pig before the challenge and at the 4^(th),7^(th) and 14 thdays after the challenge with JXA1 isolate. [Results] HSPG2 expression in Tibetan pig lung tissues increased significantly at the 4^(th) and 14 thdays after the challenge with JXA1( P < 0. 05),while decreased significantly at the 7^(th)day after the challenge( P < 0.05),HSPG2 expression in Zangmei pig lung tissues increased significantly at the 14 thday after the challenge( P < 0.05). SIGLEC1 expression in Tibetan pig lung tissues increased significantly at the 4^(th) and 14 thdays after the infection( P < 0.05),while SIGLEC1 expression in Yorkshire pig decreased significantly at the 4^(th),7^(th) and 14 thdays after the challenge( P < 0.05). CD163 expression in lung tissues of Tibetan pig and Zangmei pig both increased significantly at the 14 thday after the challenge( P < 0.05),while CD163 expression in lung tissues of Yorkshire pig decreased significantly at the 7^(th) and 14 thdays after the challenge( P < 0.05). VIM expression in lung tissues of Tibetan pig increased significantly at the 7^(th) day after the challenge( P < 0.05),while which of Yorkshire pig at the 7^(th) day after the challenge decreased significantly( P < 0.05). NMMHC-II A expression in lung tissues of Zangmei pig increased significantly at the 4^(th) day after the challenge( P < 0.05),and which of Yorkshire pig increased significantly at the 4^(th) and 14 thdays after the challenge( P < 0.05). [Conclusion]SIGLEC1 and VIM genes might be the potential key genes affecting the susceptibility of JXA1 isolate on Tibetan pig,Zangmei pig and Yorkshire pig.

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