[Objective] The aim of the research was to evaluate the protective efficacy of traditional Chinese medicine (TCM) compound against chicken colibacillosis. [Method] Two TCM preparations were obtained by modifying the proved recipes. The AA broilers were selected and challenged by E. coli. Antibacterial test in vitro and protection test in vivo were conducted to investigate the protective efficacy of the two TCM preparations A and B against chicken colibacillosis. [Result] The mortality of chickens treated with the prescription A or B was significantly lower than that of the control. The protective rates of the prescription A and B were respectively 72.1% and 81.4%, both higher than that of the control (32.5%). [Conclusion] The TCM compound A and B can be used to protect broilers from colibacillosis.
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