Antihyperglycemic effect of methanol extract of Tamarix aphylla L. Karst (Saltcedar) in streptozocin–nicotinamide induced diabetic rats

Rooh Ullah; Shafiq Ahmed Tariq; Naeem Khan; Nawaz Sharif; Zia Ud Din; Khalid Mansoor

首页> 外文期刊>亚太热带生物医学杂志（英文版） >Antihyperglycemic effect of methanol extract of Tamarix aphylla L. Karst (Saltcedar) in streptozocin–nicotinamide induced diabetic rats

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Antihyperglycemic effect of methanol extract of Tamarix aphylla L. Karst (Saltcedar) in streptozocin–nicotinamide induced diabetic rats

机译：Ta柳喀斯特（Saltcedar）甲醇提取物对链脲霉素-烟酰胺诱导的糖尿病大鼠的降血糖作用

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Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla (T. aphylla) leaves in STZ–NIC induced diabetes in Wister Albino rats. Methods: Acute toxicity study was done to check the toxicity of T. aphylla (L. Karst) methanol extract. T. aphylla leaves extract was administered intraperitoneally (100 mg, 250 mg and 400 mg/kg body weight per day) to diabetic Wister rats for 21 days. The various parameters were studied including fasting blood glucose levels, haemoglobin and glycosylated haemoglobin. Results: The treatment groups with the extract at three dose levels expressively abridged the intensities of blood glucose and Glycosylated Haemoglobin. The earlier detected reduced level of plasma haemoglobin of the diabetic rats was raised to near normalcy with treatment of extract. Conclusions: The results of the current study confirm that the leaves extract of T. aphylla are nontoxic and have antidiabetic nature.

机译：目的：评价of柳（T. aphylla）叶片在STZ–NIC诱导的Wister Albino大鼠糖尿病中的降血糖潜力。方法：进行了急性毒性研究，以检查紫苏（T. aphylla）（L。Karst）甲醇提取物的毒性。向糖尿病Wister大鼠腹膜内施用天竺葵叶片提取物（每天100mg，250mg和400mg / kg体重）21天。研究了各种参数，包括空腹血糖水平，血红蛋白和糖基化血红蛋白。结果：用三个剂量水平的提取物的治疗组明显减少了血糖和糖基化血红蛋白的强度。通过提取物的治疗，早期发现的糖尿病大鼠血浆血红蛋白降低的水平升高至接近正常。结论：目前的研究结果证实，紫苏叶提取物无毒且具有抗糖尿病作用。

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《亚太热带生物医学杂志（英文版）》 |2017年第7期|619-623|共5页
作者
Rooh Ullah; Shafiq Ahmed Tariq; Naeem Khan; Nawaz Sharif; Zia Ud Din; Khalid Mansoor;
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Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, KPK, Pakistan;

Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, KPK, Pakistan;

Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, KPK, Pakistan;

Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, KPK, Pakistan;

Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, KPK, Pakistan;

Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, KPK, Pakistan;

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Antihyperglycemic effect of methanol extract of Tamarix aphylla L. Karst (Saltcedar) in streptozocin–nicotinamide induced diabetic rats

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