Chemical constituents, in vitro antimicrobial and cytotoxic potentials of the extracts from Macaranga barteri Mull-Arg

Akintayo Ogundajo; Benjamin Okeleye; Anofi Omotayo Ashafa

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Chemical constituents, in vitro antimicrobial and cytotoxic potentials of the extracts from Macaranga barteri Mull-Arg

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Objectives: To investigate antimicrobial and cytotoxic potentials as well as chemical constituents of extracts from Macaranga barteri (M. barteri). Methods: Antimicrobial activity was carried out using micro-dilution, cell culture and GC–MS methods were employed to determine the cytotoxicity and chemical constituents of the extracts respectively. Results: Marked activity was observed in methanol (ME) fraction [MIC50: (0.0977–6.2500) mg/mL] compared to hexane and ethyl acetate fractions. Aeromonas hydrophila (environmental strain) and Shigella sonnei (ATCC 29930) were the most susceptible pathogens to ME and ciprofloxacin (Cl) at MIC50 value of 0.0977 and<0.0195 mg/mL respectively. Cryptococcus neoformans (ATCC 66031) was susceptible to ME at 0.1953 mg/mL compared to fluconazole at 10.0000 μg/mL. Decreased viability of the Vero cells was observed at the concentrations of 0.1–1.0 mg/mL. The lethal dose (LC50) of hexane, ethyl acetate and methanol fractions were recorded at (0.30 ± 0.07), (0.52 ± 0.05) and (0.22 ± 0.04) mg/mL, respectively. Some of the compounds identified from ME were caryophyllene (25.21%), neophytadiene (11.90%),α-humulene (7.67%), phytol (4.40%), ethyl ester hexadecanoic acid (4.04%) and nerolidol (2.83%) which were known to have various antimicrobial activities. Conclusions: Methanol fraction of M. barteri is a potent and safe antimicrobial and antifungal alternative which can be useful in the search for new antimicrobial drugs. The study also confirmed the orthodox usage of M. barteri in combating infectious diseases.

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《亚太热带生物医学杂志（英文版）》 |2017年第7期|654-659|共6页
作者
Akintayo Ogundajo; Benjamin Okeleye; Anofi Omotayo Ashafa;
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Phytomedicine and Phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, Qwaqwa Campus, Phuthaditjhaba 9866, South Africa;

Phytomedicine and Phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, Qwaqwa Campus, Phuthaditjhaba 9866, South Africa;

Phytomedicine and Phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, Qwaqwa Campus, Phuthaditjhaba 9866, South Africa;

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Chemical constituents, in vitro antimicrobial and cytotoxic potentials of the extracts from Macaranga barteri Mull-Arg

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