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首页> 中文期刊> 《亚太热带生物医学杂志（英文版）》 >Protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat

Protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat

         
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摘要

Objective:To study the protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat.Methods:A total of84Wistar rats were divided into4 groups:12 inGroupA(control group),24 inGroupB(diabetic cataract group),24 inGroupC(therapeutic-dose of resveratrol group) and24 inGroupD(low-dose of resveratrol group).Rats inGroupB-D were given with 60 mg/kg streptozotocin through intraperitoneal injection.Rats inGroupC were given with100 mg/kg resveratrol and rats inGroupD were given with20 mg/kg resveratrol.The caspase-3 expression levels and apoptosis ratios ofLEC among each group were observed; the degrees of lens opacity inGroupB-D after12 weeks were compared.Results:There were significant differences in caspase-3 expression levels, apoptosis ratios ofLEC among groups at4 w,8 w and 12 w(P<0.05).After12 weeks, inGroupB the degree of lens opacity was as follow:0(0.00%) in grade Ⅰ,3(37.50%) in gradeⅡ,2(25.00%)in grade Ⅲ,2(25.00%)grade Ⅳ, and1(12.50%) in grade Ⅴ; inGroupC:2(25.00%)in grade Ⅰ,4(50.00%) in gradeⅡ,2(25.00%)in grade Ⅲ,0(0.00%)grade Ⅳ, and0(0.00%) in grade Ⅴ; inGroupD:1(12.50%)in grade Ⅰ,4(50.00%) in gradeⅡ,2(25.00%) in grade Ⅲ,1(12.50%) grade Ⅳ, and0(0.00%) in grade Ⅴ.The difference amongGroupB-D was statistically significant(P<0.05).Conclusions:Resveratrol has protective effect on lens epithelial cell apoptosis in diabetic cataract rat, and the effect is relative to its dose.

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  • 来源
    《亚太热带生物医学杂志（英文版）》 |2015年第2期|153-156|共4页
  • 作者

    Hong-Min Wang; Guo-Xing Li; Han-Song Zheng; Xue-Zhi Wu;

  • 作者单位

    Center Hospital Affiliated to Zhengzhou University, Zhumadian 463000, China;

    Eye Hospital Affiliated to Wenzhou Medical College, Wenzhou 325000, China;

    Center Hospital Affiliated to Zhengzhou University, Zhumadian 463000, China;

    Center Hospital Affiliated to Zhengzhou University, Zhumadian 463000, China;

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  • 正文语种 eng
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