High levels of Zinc-α-2-Glycoprotein among Omani AIDS patients on combined antiretroviral therapy

Sidgi Syed Anwer Hasson; Mohammed Saeed Al-Balushi; Muzna Hamed Al Yahmadi; Juma Zaid Al-Busaidi; Elias Antony Said; Mohammed Shafeeq Othman; Talal Abdullah Sallam; Mohammed Ahmad Idris; Ali Abdullah Al-Jabri

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High levels of Zinc-α-2-Glycoprotein among Omani AIDS patients on combined antiretroviral therapy

机译：联合抗逆转录病毒疗法治疗阿曼艾滋病患者中锌-α-2-糖蛋白水平较高

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Objective:To investigate the levels of zinc-α-2-glycoprotein (ZAG) among Omani AIDS patients receiving combined antiretroviral therapy (cART). Methods:A total of 80 Omani AIDS patients (45 males and 35 females), average age of 36 years, who were receiving cART at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, were tested for the levels of ZAG. In addition, 80 healthy blood donors (46 males and 34 females), average age of 26 years, attending the SQUH Blood Bank, were tested in parallel as a control group. Measurement of the ZAG levels was performed using a competitive enzyme-linked immunosorbent assay and in accordance with the manufacturer’s instructions. Results:The ZAG levels were found to be significantly higher among AIDS patients compared to the healthy individuals (P=0.033). A total of 56 (70%) of the AIDS patients were found to have higher levels of ZAG and 16 (20%) AIDS patients were found to have high ZAG levels, which are significantly (P>0.031) associated with weight loss. Conclusions:ZAG levels are high among Omani AIDS patients on cART and this necessitates the measurement of ZAG on routine basis, as it is associated with weight loss.

机译：目的：研究接受抗逆转录病毒治疗（cART）的阿曼艾滋病患者中锌-α-2-糖蛋白（ZAG）的水平。方法：对阿曼马斯喀特苏丹卡布斯大学医院（SQUH）接受cART的80例阿曼艾滋病患者（男45例，女35例）进行了平均水平（36岁）的检测。 ZAG。此外，作为对照组，对参加SQUH血库的80名健康献血者（46名男性和34名女性）平均年龄为26岁进行了平行测试。 ZAG水平的测定使用竞争性酶联免疫吸附测定法，并按照制造商的说明进行。结果：与健康个体相比，发现AIDS患者中的ZAG水平显着更高（P = 0.033）。发现总共56（70％）艾滋病患者的ZAG水平较高，而发现16（20％）AIDS患者的ZAG水平较高，这与体重减轻显着相关（P> 0.031）。结论：使用cART的阿曼艾滋病患者中ZAG含量很高，这需要常规测量ZAG，因为它与体重减轻有关。

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《亚太热带生物医学杂志（英文版）》 |2014年第8期|610-613|共4页
作者
Sidgi Syed Anwer Hasson; Mohammed Saeed Al-Balushi; Muzna Hamed Al Yahmadi; Juma Zaid Al-Busaidi; Elias Antony Said; Mohammed Shafeeq Othman; Talal Abdullah Sallam; Mohammed Ahmad Idris; Ali Abdullah Al-Jabri;
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Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.0. Box 35, Muscat, 0man;

Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.0. Box 35, Muscat, 0man;

Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.0. Box 35, Muscat, 0man;

Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.0. Box 35, Muscat, 0man;

Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.0. Box 35, Muscat, 0man;

Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.0. Box 35, Muscat, 0man;

Department of Community Health, Faculty of Applied Medical Sciences, Al-Baha University, Saudi Arabia;

Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.0. Box 35, Muscat, 0man;

Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.0. Box 35, Muscat, 0man;

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High levels of Zinc-α-2-Glycoprotein among Omani AIDS patients on combined antiretroviral therapy

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