Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with asymptomatic malaria in a rural community in Burkina Faso

Abdoul Karim Ouattara; Cyrille Bisseye; Birama Diarra; Tegwind Rebeca Compaore; Florencia Djigma; Virginio Pietra; Remy Moret; Jacques Simpore

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with asymptomatic malaria in a rural community in Burkina Faso

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Objective: To investigate 4 combinations of mutations responsible for glucose-6-phosphate dehydrogenase (G6PD) deficiency in a rural community of Burkina Faso, a malaria endemic country. Methods: Two hundred individuals in a rural community were genotyped for the mutations A376G, G202A, A542T, G680T and T968C using TaqMan single nucleotide polymorphism assays and polymerase chain reaction followed by restriction fragment length polymorphism. Results: The prevalence of the G6PD deficiency was 9.5% in the study population. It was significantly higher in men compared to women (14.3%vs 6.0%, P=0.049). The 202A/376G G6PD A-was the only deficient variant detected. Plasmodium falciparum asymptomatic parasitaemia was significantly higher among the G6PD-non-deficient persons compared to the G6PD-deficient (P<0.001). The asymptomatic parasitaemia was also significantly higher among G6PD non-deficient compared to G6PD-heterozygous females (P<0.001). Conclusions:This study showed that the G6PD A-variant associated with protection against asymptomatic malaria in Burkina Faso is probably the most common deficient variant.

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《亚太热带生物医学杂志（英文版）》 |2014年第8期|655-658|共4页
作者
Abdoul Karim Ouattara; Cyrille Bisseye; Birama Diarra; Tegwind Rebeca Compaore; Florencia Djigma; Virginio Pietra; Remy Moret; Jacques Simpore;
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Centre for Biomolecular Research Pietro Annigoni CERBA LABI0GENE UFR/SVT, University of 0uagadougou BP 364 0uagadougou, Burkina Faso;

Centre for Biomolecular Research Pietro Annigoni CERBA LABI0GENE UFR/SVT, University of 0uagadougou BP 364 0uagadougou, Burkina Faso;

Centre for Biomolecular Research Pietro Annigoni CERBA LABI0GENE UFR/SVT, University of 0uagadougou BP 364 0uagadougou, Burkina Faso;

Centre for Biomolecular Research Pietro Annigoni CERBA LABI0GENE UFR/SVT, University of 0uagadougou BP 364 0uagadougou, Burkina Faso;

Centre for Biomolecular Research Pietro Annigoni CERBA LABI0GENE UFR/SVT, University of 0uagadougou BP 364 0uagadougou, Burkina Faso;

Centre for Biomolecular Research Pietro Annigoni CERBA LABI0GENE UFR/SVT, University of 0uagadougou BP 364 0uagadougou, Burkina Faso;

Centre for Biomolecular Research Pietro Annigoni CERBA LABI0GENE UFR/SVT, University of 0uagadougou BP 364 0uagadougou, Burkina Faso;

Centre for Biomolecular Research Pietro Annigoni CERBA LABI0GENE UFR/SVT, University of 0uagadougou BP 364 0uagadougou, Burkina Faso;

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with asymptomatic malaria in a rural community in Burkina Faso

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