Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity:an in vitro study

Hakan Syt; Elif Duygu Kaya; kr Beydemir

首页> 中文期刊> 《亚太热带生物医学杂志（英文版）》 >Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity:an in vitro study

Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity:an in vitro study

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Objective:To investigate the in vitro effects of the antibacterial drugs, meropenem trihydrate, piperacillin sodium, and cefoperazone sodium, on the activity of human serum paraoxonase Methods: hPON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration chromatography. Results:The three antibacterial drugs decreased in vitro hPON1 activity. Inhibition mechanisms meropenem trihydrate was noncompetitive while piperacillin sodium and cefoperazone sodium were competitive. Conclusions:Our results showed that antibacterial drugs significantly inhibit hPON1 activity, both in vitro, with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro.

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《亚太热带生物医学杂志（英文版）》 |2014年第8期|603-609|共7页
作者
Hakan Syt; Elif Duygu Kaya; kr Beydemir;
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Department of Primary Education, Faculty of Education, Bayburt University, 69000 Bayburt, Turkey;

Department of Food Engineering, Faculty of Engineering, Iğdır University, 76000 Iğdır, Turkey;

Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey;

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Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity:an in vitro study

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