GC/GCMS analysis of the petroleum ether and dichloromethane extracts of Moringa oleifera roots

Shaheen Faizi; Saima Sumbul; Muhammed Ali Versiani; Rubeena Saleem; Aisha Sana; Hira Siddiqui

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GC/GCMS analysis of the petroleum ether and dichloromethane extracts of Moringa oleifera roots

机译：辣木根石油醚和二氯甲烷提取物的GC / GCMS分析

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Objective:To explore the phytochemical constituents from petroleum ether and dichloromethane extracts of Moringa oleifera (M. oleifera) roots using GC/GC-MS. Methods: A total of 5.11 kg fresh and undried crushed root of M. oleifera were cut into small pieces and extracted with petroleum ether and dichloromethane (20 L each) at room temperature for 2 d. The concentrated extracts were subjected to their GC-MS analysis. Results:The GC-MS analysis of the petroleum ether and dichloromethane extracts of M. oleifera roots, which showed promising biological activities, has resulted in the identification 102 compounds. These constituents belong to 15 classes of compounds including hydrocarbons, fatty acids, esters, alcohols, isothiocyanate, thiocyanate, pyrazine, aromatics, alkamides, cyanides, steroids, halocompounds, urea and N-hydroxyimine derivatives, unsaturated alkenamides, alkyne and indole. GC/GC-MS studies on petroleum ether extract of the roots revealed that it contained 39 compounds, belonging to nine classes. Cyclooctasulfur S8 has been isolated as a pure compound from the extract. The major compounds identified from petroleum ether extract were trans-13-docosene (37.9%), nonacosane (32.6%), cycloartenol (28.6%) nonadecanoic acid (13.9%) and cyclooctasulfur S8 (13.9%). Dichloromethane extract of the roots was composed of 63 compounds of which nasimizinol (58.8%) along with oleic acid (46.5%), N-benzyl-N-(7-cyanato heptanamide (38.3%), N-benzyl-N-(1-chlorononyl) amide (30.3%), bis [3-benzyl prop-2-ene]-1-one (19.5%) and N, N-dibenzyl-2-ene pent 1, 5-diamide (11.6%) were the main constituents. Conclusions:This study helps to predict the formula and structure of active molecules which can be used as drugs. This result also enhances the traditional usage of M. oleifera which possesses a number of bioactive compounds.

机译：目的：利用GC / GC-MS研究辣木根的石油醚和二氯甲烷提取物中的植物化学成分。方法：将5.11 kg新鲜的和未干燥的油杨毛的根切成小块，并在室温下用石油醚和二氯甲烷（各20 L）萃取2 d。对浓缩的提取物进行GC-MS分析。结果：GC-MS分析油茶根的石油醚和二氯甲烷提取物，显示出有希望的生物活性，已鉴定出102种化合物。这些成分属于15类化合物，包括烃，脂肪酸，酯，醇，异硫氰酸酯，硫氰酸酯，吡嗪，芳烃，烷酰胺，氰化物，类固醇，卤化物，尿素和N-羟基亚胺衍生物，不饱和链烯酰胺，炔烃和吲哚。对根的石油醚提取物进行的GC / GC-MS研究表明，它含有39种化合物，属于9类。已从提取物中分离出作为纯化合物的环辛硫S8。从石油醚提取物中鉴定出的主要化合物为反式13-二十二烯（37.9％），壬二烷（32.6％），环烯醇（28.6％）壬二酸（13.9％）和环辛硫S8（13.9％）。根部的二氯甲烷提取物由63种化合物组成，其中那西米辛（58.8％）连同油酸（46.5％），N-苄基-N-（7-氰基庚酰胺（38.3％），N-苄基-N-（1 -氯壬基）酰胺（30.3％），双[3-苄基丙-2-烯] -1-酮（19.5％）和N，N-二苄基-2-烯戊1、5-二酰胺（11.6％）是结论：这项研究有助于预测可用作药物的活性分子的组成和结构，这一结果也增强了传统的油松分枝杆菌的用途，因为它具有许多生物活性化合物。

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《亚太热带生物医学杂志（英文版）》 |2014年第8期|650-654|共5页
作者
Shaheen Faizi; Saima Sumbul; Muhammed Ali Versiani; Rubeena Saleem; Aisha Sana; Hira Siddiqui;
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HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan;

HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan;

Department of Chemistry, Federal Urdu University of Arts, Sciences and Technology, Gulshan-e-Iqbal, Science Campus, Karachi-75300, Pakistan;

Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi-74600, Pakistan;

Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi-74600, Pakistan;

Department of Chemistry, Federal Urdu University of Arts, Sciences and Technology, Gulshan-e-Iqbal, Science Campus, Karachi-75300, Pakistan;

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GC/GCMS analysis of the petroleum ether and dichloromethane extracts of Moringa oleifera roots

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