The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

Kwabena Obeng Duedu; Kwamena William Coleman Sagoe; Patrick Ferdinand Ayeh-Kumi; Raymond Bedu Affrim; Theophilus Adiku

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The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

机译：人细小病毒B19和恶性疟原虫共同感染对加纳儿童贫血类型和程度的影响

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Objective:To determin the extent to which parvovirus B19 (B19V) and co-infection of B19V and malaria contribute to risk of anaemia in children. Methods: B19V DNA and malaria parasites were screened for 234 children at the PML Children’s Hospital in Accra. The role of B19V and co-infection with B19V and malaria in anaemia was evaluated by analysing full blood cell counts, malaria and B19V DNA results from these children. Results: The prevalence of B19V, malaria and co-infection with B19V and malaria was 4.7%, 41.9%and 2.6%, respectively. Malaria posed a greater risk in the development of mild anaemia compared to severe anaemia (OR=5.28 vrs 3.15) whereas B19V posed a higher risk in the development of severe anaemia compared to mild anaemia (OR=4.07 vrs 1.00) from a non-anaemic child. Persons with co-infection with B19V and malaria had 2.23 times the risk (95%CI=0.40-12.54) of developing severe anaemia should they already have a mild anaemia. The degree of anaemia was about three times affected by co-infection (Pillai’s trace=0.551, P=0.001) as was affected by malaria alone (Pillai’s trace=0.185, P=0.001). B19V alone did not significantly affect the development of anaemia in a non-anaemic child. Microcytic anaemia was associated with B19V and co-infection with B19V and malaria more than normocytic normochromic anaemia. Conclusions: B19V was associated with malaria in cases of severe anaemia. The association posed a significant risk for exacerbation of anaemia in mild anaemic children. B19V and co-infection with B19V and malaria may be associated with microcytic anaemia rather than normocytic normochromic anaemia as seen in cases of B19V infection among persons with red cell abnormalities.

机译：目的：确定细小病毒B19（B19V）以及B19V与疟疾的共同感染在多大程度上导致儿童患贫血的风险。方法：在阿克拉的PML儿童医院筛查了234名儿童的B19V DNA和疟疾寄生虫。通过分析这些儿童的全血细胞计数，疟疾和B19V DNA结果，评估了B19V以及与B19V和疟疾共感染的作用。结果：B19V，疟疾以及与B19V和疟疾的合并感染的患病率分别为4.7％，41.9％和2.6％。与轻度贫血相比，疟疾对轻度贫血的发展具有更高的风险（OR = 5.28 vrs 3.15），而与非贫血相比，B19V对轻度贫血的发展具有较高的风险（OR = 4.07 vrs 1.00）儿童。如果他们已经患有轻度贫血，则与B19V和疟疾同时感染的人患严重贫血的风险（95％CI = 0.40-12.54）是其的2.23倍。贫血程度受合并感染的影响约为三倍（Pillai踪迹= 0.551，P = 0.001），而仅受疟疾的影响（Pillai踪迹= 0.185，P = 0.001）。单独的B19V不会显着影响非贫血儿童的贫血发展。与正常血红细胞性贫血相比，小细胞性贫血与B19V以及与B19V和疟疾共感染的相关性更高。结论：B19V与严重贫血患者的疟疾有关。该协会给轻度贫血儿童带来了严重的贫血风险。 B19V以及与B19V和疟疾的共同感染可能与小红细胞性贫血有关，而不是与红血球异常的人发生B19V感染的情况下的正常红细胞性常色性贫血有关。

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来源
《亚太热带生物医学杂志（英文版）》 |2013年第2期|129-139|共11页
作者
Kwabena Obeng Duedu; Kwamena William Coleman Sagoe; Patrick Ferdinand Ayeh-Kumi; Raymond Bedu Affrim; Theophilus Adiku;
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Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana;

Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana;

Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana;

Laboratory Department, Princess Marie Louis Children’s Hospital, Derby Avenue, Accra, Ghana;

Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana;

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The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

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