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首页> 外文期刊>亚太热带生物医学杂志（英文版） >A study of in vitro antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand
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A study of in vitro antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand

机译：四齿席夫碱配体镧系元素配合物的体外抗菌活性研究

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Objective: To establish the antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand L. Methods: (N, N'-bis (1-naphthaldimine)-o-phenylenediamine) was prepared from the condensation of 2-hydroxy-1-naphthaldehyde with o-phenylenediamine in a molar ratio of 2:1. The antimicrobial activity of the resultant Ln (III) complexes was investigated using agar well diffusion and micro-broth dilution techniques; the latter was used to establish the minimum inhibitory concentrations for each compound investigated. Results: Most of Ln (III) complexes were found to exhibit antibacterial activities against a number of pathogenic bacteria with MICs ranging between 1.95-250.00 μg/mL. Staphylococcus aureus was the most susceptible bacterial species to [LaL(NO3)2(H2O)](NO3) complex while Shigella dysenteriae andEscherichia coli required a relatively higher MIC (250 μg/mL). The complexes La (III) and Pr (III) were effective inhibitors against Staphylococcus aureus, whereas Sm (III) complex was effective against Serratia marcescens. On the other hand, Gd (III), La (III) and Nd (III) were found to be more potent inhibitors against Pseudomonas aeruginosa than two of commonly used antibiotics. The remaining Ln (III) complexes showed no remarkable activity as compared to the two standard drugs used. Conclusions: Tetradentate Schiff base ligand L and its complexes could be a potential antibacterial compounds after further investigation.
机译：目的：建立具有四齿席夫碱配体L的镧系元素配合物的抗菌活性。方法：由2-羟基-1-萘醛缩合制得N，N'-双（1-萘二胺）-邻苯二胺。与邻苯二胺的摩尔比为2：1。使用琼脂井扩散和微肉汤稀释技术研究了所得Ln（III）复合物的抗菌活性;后者用于确定所研究的每种化合物的最低抑菌浓度。结果：发现大多数Ln（III）复合物对多种病原菌均表现出抗菌活性，其MIC在1.95-250.00μg/ mL之间。金黄色葡萄球菌是对[LaL（NO3）2（H2O）]（NO3）复合物最敏感的细菌，而痢疾志贺氏菌和大肠杆菌则需要相对较高的MIC（250μg/ mL）。配合物La（III）和Pr（III）是抗金黄色葡萄球菌的有效抑制剂，而Sm（III）配合物对粘质沙雷氏菌有效。另一方面，与两种常用抗生素相比，发现Gd（III），La（III）和Nd（III）是更有效的铜绿假单胞菌抑制剂。与使用的两种标准药物相比，其余的Ln（III）复合物没有显示出明显的活性。结论：四齿席夫碱配体L及其配合物经进一步研究可能是潜在的抗菌化合物。

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